Chen Shengyun, Liu Yaxi, Liu Dennis, Zhang Guican, Wu Xiaoli
Psychiatry Department, The 3rd Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Northern Adelaide Local Health Network, Adelaide, SA, Australia.
Schizophr Res Cogn. 2021 Feb 25;24:100195. doi: 10.1016/j.scog.2021.100195. eCollection 2021 Jun.
To explore the specific features of cognitive function in patients with schizophrenia at different stages and its influencing factors.
The MATRICS Consensus Cognitive Battery (MCCB) and the Brief Psychiatric Rating Scale (BPRS) were administered to 208 patients with schizophrenia, including 158 clinically stable schizophrenia (CSS) and 50 first-episode patients with schizophrenia (FES), and 40 healthy controls (HC). Propensity score matching (PSM) was used to match the CSS and FES.
(1) The MCCB and its sub-scale scores in patients with schizophrenia were lower than HC, but the score of emotion intelligence showed no significant difference between CSS and HC. (2) Before PSM, the cognitive scores of FES were significantly lower than CSS (except trail making A test, Hopkins verbal learning, category fluency). After PSM, patients with CSS still do better in performing trail making A test, emotional intelligence, continuous performances and MCCB total score. (3) BPRS total score, gender, group (FES vs CSS) and age were independent contributors to emotion intelligence, and BPRS total score had the biggest effect. (4) The effect of group (FES vs CSS) on MCCB total score and emotional intelligence was statistically significant.
There are significant cognitive deficits in patients with FES and CSS compared with HC. FES have greater cognitive impairments compared with CSS. Emotion intelligence of CSS may be even close to the level of HC. BPRS total score, gender, group (FES vs CSS) and age may be the independent contributors to social cognition. Group (FES vs CSS) may play an important effect on general cognition and social cognition.
探讨精神分裂症患者不同阶段认知功能的特点及其影响因素。
对208例精神分裂症患者进行了MATRICS共识认知成套测验（MCCB）和简明精神病评定量表（BPRS）评估，其中包括158例临床稳定的精神分裂症患者（CSS）和50例首发精神分裂症患者（FES），并选取40名健康对照者（HC）。采用倾向得分匹配法（PSM）对CSS组和FES组进行匹配。
（1）精神分裂症患者的MCCB及其子量表得分低于HC组，但CSS组与HC组在情商得分上无显著差异。（2）在PSM之前，FES组的认知得分显著低于CSS组（除数字符号A测验、霍普金斯词语学习、类别流畅性外）。PSM后，CSS组患者在数字符号A测验、情商、持续性操作测验及MCCB总分方面仍表现更好。（3）BPRS总分、性别、分组（FES组与CSS组）和年龄是情商的独立影响因素，其中BPRS总分影响最大。（4）分组（FES组与CSS组）对MCCB总分和情商的影响具有统计学意义。
与HC组相比，FES组和CSS组患者均存在明显的认知缺陷。FES组比CSS组存在更严重的认知损害。CSS组的情商可能接近HC组水平。BPRS总分、性别、分组（FES组与CSS组）和年龄可能是社会认知的独立影响因素。分组（FES组与CSS组）可能对一般认知和社会认知起重要作用。
