Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt.
East Mediterr Health J. 2009 Jul-Aug;15(4):807-16.
This study assessed changes in serum levels of cytokines IFNgamma and IL-10 (biomarkers of inflammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothelial dysfunction) in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis.
本研究评估了伴有和不伴有肾病的糖尿病患者血清细胞因子 IFNgamma 和 IL-10（炎症变化的生物标志物）以及可溶性生物标志物 sICAM-1 和 sE-selectin（血管内皮功能障碍的生物标志物）水平的变化。与对照组和无糖尿病肾病（DN）的糖尿病患者相比，糖尿病肾病（DN）和终末期肾病（ESRD）患者的 IFNgamma 和 IL-10 显著升高。血液透析后 IFNgamma 和 IL-10 水平显著升高。与对照组相比，糖尿病组、DN 组和 ESRD 组的 sICAM-1 和 sE-selectin 显著升高，血液透析后 sICAM-1 而非 sE-selectin 升高。
