Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, N. Kargar Street, Tehran, Iran.
Arch Iran Med. 2010 Mar;13(2):99-104.
In older studies, the seroprevalence of hepatitis A virus infection has been reported to be over 95% in Iranians. Most of these studies were performed on volunteer blood donors. Studies on the general population are sparse. The purpose of this study was to determine the current seroprevalence of hepatitis A virus infection in the general population of Iran.
During 2006, 1869 subjects between 18 and 65 years of age were randomly selected from the general population of three Iranian provinces (Tehran, Golestan, and Hormozgan). Subjects were interviewed and a plasma sample was obtained for serologic testing for anti-hepatitis A virus. Univariate and multivariate analysis was performed to identify risk factors.
The seroprevalence of hepatitis A virus in Tehran, Golestan and Hormozgan was 85%, 99%, and 96%, respectively. The overall seroprevalence of hepatitis A virus in the general population of the three provinces studied was 86% and did not differ between the two genders. The prevalence in younger subjects and in urban populations was under 70%. In multivariate analysis, older age, being married, and level of the father's education was associated with hepatitis A virus seropositivity.
The seroprevalence of hepatitis A virus still appears to be too elevated for recommending routine vaccination in the general population. However, the trend towards a lower prevalence in younger age groups and people from urban areas points towards the possible benefit of vaccination in these subgroups.
在之前的研究中，伊朗超过 95%的成年人曾感染过甲型肝炎病毒。这些研究大多是在志愿献血者中进行的。针对普通人群的研究则相对较少。本研究旨在确定目前伊朗普通人群中甲型肝炎病毒的感染率。
2006 年，我们从伊朗三个省份（德黑兰、戈勒斯坦和霍尔木兹甘）的普通人群中随机抽取了 1869 名年龄在 18 至 65 岁之间的个体。对这些个体进行了访谈，并采集了血浆样本，用于检测抗甲型肝炎病毒的抗体。采用单变量和多变量分析来确定危险因素。
德黑兰、戈勒斯坦和霍尔木兹甘的甲型肝炎病毒血清流行率分别为 85%、99%和 96%。这三个省份的普通人群的甲型肝炎病毒总血清流行率为 86%，且在性别之间没有差异。在年轻组和城市人群中的流行率低于 70%。多变量分析显示，年龄较大、已婚以及父亲的教育程度与甲型肝炎病毒血清阳性相关。
甲型肝炎病毒的血清流行率似乎仍然过高，不建议在普通人群中进行常规疫苗接种。然而，在年龄较小的人群和城市地区人群中流行率较低的趋势表明，在这些亚组中接种疫苗可能会带来益处。
