The Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, 7th floor, Taleghani Hospital, Yaman Ave., Velenjak, PO Box 19835-187, Tehran, Iran.
Trans R Soc Trop Med Hyg. 2012 Sep;106(9):528-31. doi: 10.1016/j.trstmh.2012.05.013. Epub 2012 Jul 24.
Hepatitis A virus (HAV) and hepatitis E virus (HEV) are enteric hepatotropic viruses and their prevalence is related to the sanitary conditions of the region under investigation. There are only a few studies on the seroepidemiology of these two viruses in the general Iranian population. The purpose of this investigation was to measure the prevalence of hepatitis A and E infections in the general population. Between 2006 and 2007, a cross sectional study was performed in Tehran, Iran. Blood specimens were collected and questionnaires were filled in for 551 persons. Patient sera were tested by ELISA for anti-HEV and anti-HAV IgGs. The χ(2) test and independent t-test were used for statistical analysis and p<0.05 was considered significant. The overall seroprevalence rates of anti-HEV IgG and anti-HAV IgG were 9.3% and 90%, respectively. The prevalence of antibodies to HAV and HEV was greater among men than women and increased with age. However, there was no significant relationship between age and gender with the existence of anti- HAV and HEV IgG antibodies. Our results show the seroprevalence of HAV and HEV antibodies are high and both viruses are endemic in this region. These findings are in accordance with results obtained from previous studies. We recommend that foreign travelers to Iran are vaccinated against HAV.
甲型肝炎病毒（HAV）和戊型肝炎病毒（HEV）是肠道嗜肝病毒，其流行与所调查地区的卫生条件有关。关于这两种病毒在伊朗普通人群中的血清流行病学仅有少数研究。本研究旨在测量普通人群中甲型肝炎和戊型肝炎感染的流行率。2006 年至 2007 年，在伊朗德黑兰进行了一项横断面研究。采集了 551 人的血样并填写了问卷。通过 ELISA 法检测患者血清中的抗-HEV 和抗-HAV IgG。采用 χ(2)检验和独立 t 检验进行统计学分析，p<0.05 为差异有统计学意义。抗-HEV IgG 和抗-HAV IgG 的总血清阳性率分别为 9.3%和 90%。抗 HAV 和 HEV 的抗体在男性中的流行率高于女性，并随年龄增长而增加。然而，抗 HAV 和 HEV IgG 抗体的存在与年龄和性别之间没有显著关系。我们的结果表明 HAV 和 HEV 抗体的血清阳性率较高，这两种病毒在该地区流行。这些发现与以前的研究结果一致。我们建议前往伊朗的外国旅行者接种 HAV 疫苗。
