Headache Group - Department of Neurology, University of California, San Francisco, San Francisco, CA 94115, USA.
Expert Rev Neurother. 2010 Mar;10(3):389-411. doi: 10.1586/ern.10.16.
In recent years bench-based studies have greatly enhanced our understanding of headache pathophysiology, while facilitating the development of new headache medicines. At present, established animal models of headache utilize activation of pain-producing cranial structures, which for a complex syndrome, such as migraine, leaves many dimensions of the syndrome unstudied. The focus on modeling the central nociceptive mechanisms and the complexity of sensory phenomena that accompany migraine may offer new approaches for the development of new therapeutics. Given the complexity of the primary headaches, multiple approaches and techniques need to be employed. As an example, recently a model for trigeminal autonomic cephalalgias has been tested successfully, while by contrast, a satisfactory model of tension-type headache has been elusive. Moreover, although useful in many regards, migraine models are yet to provide a more complete picture of the disorder.
近年来，基于实验台的研究极大地增进了我们对头痛病理生理学的理解，同时也促进了新头痛药物的开发。目前，已确立的头痛动物模型利用激活产生疼痛的颅结构，对于偏头痛等复杂综合征而言，这留下了许多综合征的未研究维度。对中枢敏化机制和偏头痛伴随的感觉现象的复杂性的建模可能为新疗法的开发提供新方法。鉴于原发性头痛的复杂性，需要采用多种方法和技术。例如，最近已经成功测试了三叉神经自主头痛的模型，而相比之下，紧张型头痛的满意模型仍然难以捉摸。此外，尽管偏头痛模型在许多方面都很有用，但仍未能更全面地描绘出这种疾病。
