Bendtsen Lars
Copenhagen Headache Research Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Curr Opin Investig Drugs. 2002 Mar;3(3):449-53.
The pathophysiology of the two most common primary headaches, migraine and tension-type headache, is complex and not yet fully understood. Recent animal and human studies examining these headaches indicate that the nociceptive input to the central nervous system (CNS) may be increased due to activation or sensitization of peripheral sensory afferents. The barrage of nociceptive impulses may result in sensitization of second- and third-order neurons in the CNS. In this way, sensitization may play a role in initiation and maintenance of migraine and tension-type headache. It is likely that the effects of established medication for both disorders may be partly due to a reduction in sensitization. Several interesting drugs that counteract sensitization are under development, and targeting this mode of action seems to be a promising way of improving the treatment for these prevalent disorders.
两种最常见的原发性头痛——偏头痛和紧张型头痛的病理生理学很复杂，尚未完全明确。近期针对这些头痛进行的动物和人体研究表明，由于外周感觉传入神经的激活或敏化，中枢神经系统（CNS）的伤害性输入可能会增加。伤害性冲动的大量传入可能会导致中枢神经系统中二级和三级神经元的敏化。通过这种方式，敏化可能在偏头痛和紧张型头痛的发作及维持中起作用。这两种疾病的现有药物的作用效果可能部分归因于敏化作用的减弱。几种可对抗敏化作用的有趣药物正在研发中，针对这种作用方式似乎是改善这些常见疾病治疗方法的一种有前景的途径。
