Favrot Claude, Steffan Jean, Seewald Wolfgang, Picco Federicca
Clinical for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.
Vet Dermatol. 2010 Feb;21(1):23-31. doi: 10.1111/j.1365-3164.2009.00758.x.
Canine atopic dermatitis (CAD) is a multifaceted disease associated with exposure to various offending agents such as environmental and food allergens. The diagnosis of this condition is difficult because none of the typical signs are pathognomonic. Sets of criteria have been proposed but are mainly used to include dogs in clinical studies. The goals of the present study were to characterize the clinical features and signs of a large population of dogs with CAD, to identify which of these characteristics could be different in food-induced atopic dermatitis (FIAD) and non-food-induced atopic dermatitis (NFIAD) and to develop criteria for the diagnosis of this condition. Using simulated annealing, selected criteria were tested on a large and geographically widespread population of pruritic dogs. The study first described the signalment, history and clinical features of a large population of CAD dogs, compared FIAD and NFIAD dogs and confirmed that both conditions are clinically indistinguishable. Correlations of numerous clinical features with the diagnosis of CAD are subsequently calculated, and two sets of criteria associated with sensitivity and specificity ranging from 80% to 85% and from 79% to 85%, respectively, are proposed. It is finally demonstrated that these new sets of criteria provide better sensitivity and specificity, when compared to Willemse and Prélaud criteria. These criteria can be applied to both FIAD and NFIAD dogs.
犬特应性皮炎（CAD）是一种多方面的疾病，与接触各种致病因素有关，如环境和食物过敏原。这种疾病的诊断很困难，因为没有任何典型症状具有诊断特异性。已经提出了一系列标准，但主要用于临床研究中纳入犬只。本研究的目的是描述大量患有CAD的犬只的临床特征和症状，确定哪些特征在食物性特应性皮炎（FIAD）和非食物性特应性皮炎（NFIAD）中可能不同，并制定这种疾病的诊断标准。使用模拟退火算法，在大量且地域分布广泛的瘙痒犬群体上测试选定的标准。该研究首先描述了大量CAD犬只的特征、病史和临床特征，比较了FIAD犬和NFIAD犬，并证实这两种情况在临床上无法区分。随后计算了众多临床特征与CAD诊断的相关性，并提出了两组标准，其敏感性和特异性分别为80%至85%和79%至85%。最终证明，与Willemse和Prélaud标准相比，这些新的标准集具有更好的敏感性和特异性。这些标准可应用于FIAD和NFIAD犬只。
