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基于陆地的运动是否可以减轻与髋骨骨关节炎相关的疼痛和残疾?一项随机对照试验的荟萃分析。

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials.

机构信息

Faculty of Health Sciences, Clinical and Rehabilitation Sciences Research Group, University of Sydney, Australia.

出版信息

Osteoarthritis Cartilage. 2010 May;18(5):613-20. doi: 10.1016/j.joca.2010.01.003. Epub 2010 Feb 10.

DOI:10.1016/j.joca.2010.01.003
PMID:20188228
Abstract

OBJECTIVE

To determine if clinical guidelines recommending therapeutic exercise for people with hip osteoarthritis (OA) are supported by rigorous scientific evidence.

METHODS

A meta-analysis of randomized controlled trials (RCTs) recruiting people with hip OA and comparing some form of land-based exercise program (as opposed to exercises conducted in the water) with a non-exercise group in terms of hip pain and/or self-reported physical function.

RESULTS

Thirty-two RCTs were identified, but only five met the inclusion criteria. Only one of the five included RCTs restricted recruitment to people with hip OA, the other four RCTs also recruiting participants with knee OA. The five included studies provided data on 204 and 187 hip OA participants for pain and physical function, respectively. Combining the results of the five included RCTs using a fixed-effects model demonstrated a small treatment effect for pain (standardized mean difference (SMD) -0.38; 95% confidence interval (CI) -0.67 to -0.09). No significant benefit in terms of improved self-reported physical function was detected (SMD -0.02; 95% CI -0.31 to 0.28).

CONCLUSION

Currently there is only silver level evidence (one small RCT) supporting the benefit of land-based therapeutic exercise for people with symptomatic hip OA in terms of reduced pain and improved physical function. The limited number and small sample size of the included RCTs restricts the confidence that can be attributed to these results.

摘要

目的

确定针对髋骨关节炎(OA)患者推荐治疗性运动的临床指南是否有严格的科学证据支持。

方法

对招募髋 OA 患者的随机对照试验(RCT)进行荟萃分析,并比较某种形式的陆地运动方案(与水中运动相反)与非运动组在髋骨疼痛和/或自我报告的身体功能方面的差异。

结果

确定了 32 项 RCT,但只有 5 项符合纳入标准。这 5 项纳入的 RCT 中,只有 1 项限制了招募对象为髋 OA 患者,其余 4 项 RCT 也招募了膝 OA 患者。这 5 项纳入研究分别提供了 204 名和 187 名髋 OA 患者的疼痛和身体功能数据。使用固定效应模型合并这 5 项纳入 RCT 的结果显示,疼痛方面的治疗效果较小(标准化均数差(SMD)-0.38;95%置信区间(CI)-0.67 至-0.09)。在改善自我报告的身体功能方面,没有发现显著的益处(SMD-0.02;95%CI-0.31 至 0.28)。

结论

目前仅有银级证据(一项小型 RCT)支持对有症状的髋 OA 患者进行陆地治疗性运动,可减轻疼痛和改善身体功能。纳入的 RCT 数量有限且样本量小,限制了对这些结果的信任程度。

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