Greenwich University, School of Science, Medway Campus, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
Colloids Surf B Biointerfaces. 2010 Jun 1;77(2):227-33. doi: 10.1016/j.colsurfb.2010.01.031. Epub 2010 Feb 4.
The aim of the current study was the development of theophylline buccal adhesive tablets using direct compression. Buccal adhesive formulations were developed using a water soluble resin with various combinations of mucoadhesive polymers. The prepared theophylline tablets were evaluated for tensile strength, swelling capacity and ex vivo mucoadhesion performance. Ex vivo mucoadhesion was assessed using porcine gingival tissue and the peak detachment forces were found to be suitable for a buccal adhesive tablet with a maximum of 1.5 N approximately. The effect of formulation composition on the release pattern was also investigated. Most formulations showed theophylline controlled release profiles depended on the grade and polymer ratio. The release mechanisms were found to fit Peppas' kinetic model over a period of 5h. In general the majority of the developed formulations presented suitable adhesion and controlled drug release.
本研究旨在开发茶碱颊用黏附片，采用直接压缩法。颊用黏附制剂采用水溶性树脂与各种黏附聚合物组合制成。制备的茶碱片进行拉伸强度、溶胀能力和离体黏膜黏附性能的评估。离体黏膜黏附性采用猪牙龈组织进行评估，发现最大峰值分离力适用于颊用黏附片，约为 1.5N 左右。还研究了配方组成对释放模式的影响。大多数制剂显示出茶碱的控制释放模式取决于等级和聚合物的比例。发现释放机制在 5 小时内符合 Peppas 动力学模型。总的来说，大多数开发的制剂具有合适的黏附性和药物控制释放性。
