Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Neuron. 2010 Feb 25;65(4):437-9. doi: 10.1016/j.neuron.2010.02.010.
The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk gene DISC1 can alter prefrontal cortex neurochemistry, architecture, and function.
随着 Niwa 等人的报告指出,短暂减少精神分裂症风险基因 DISC1 会改变前额叶皮层的神经化学、结构和功能,早期大脑发育中的侮辱是如何导致精神障碍在受影响多年后发作的机制变得不那么神秘了。