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现在你看到了，现在你又看不到了——接近身心失调和精神障碍的发展基础。

Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders.

机构信息

Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.

出版信息

Neuron. 2010 Feb 25;65(4):437-9. doi: 10.1016/j.neuron.2010.02.010.

DOI:10.1016/j.neuron.2010.02.010
PMID:20188647
Abstract

The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk gene DISC1 can alter prefrontal cortex neurochemistry, architecture, and function.

摘要

随着 Niwa 等人的报告指出，短暂减少精神分裂症风险基因 DISC1 会改变前额叶皮层的神经化学、结构和功能，早期大脑发育中的侮辱是如何导致精神障碍在受影响多年后发作的机制变得不那么神秘了。

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Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders.现在你看到了，现在你又看不到了——接近身心失调和精神障碍的发展基础。
Neuron. 2010 Feb 25;65(4):437-9. doi: 10.1016/j.neuron.2010.02.010.
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Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.精神分裂症相关基因1和神经调节蛋白1是斑马鱼大脑中少突胶质细胞和神经元特化所必需的。
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Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory.DISC1/TRAX单倍型与精神分裂症、前额叶灰质减少以及短期和长期记忆受损之间的关联。
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Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.Nurr1表达降低的成年小鼠：一种精神分裂症动物模型。
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