Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National University, Yuseong-Gu, Daejeon 305-764, Republic of Korea.
Vaccine. 2010 Apr 9;28(17):2957-64. doi: 10.1016/j.vaccine.2010.02.016. Epub 2010 Feb 25.
The highly pathogenic H5N1 influenza viruses are one of candidates for the next pandemic. Information on protective immunity for pregnant animals by vaccination against the H5N1 influenza virus is limited. Here, we show that the immunization of pregnant mice with inactivated H5N1 influenza vaccine protects them, their fetuses, and their infant mice from H5N1 influenza viruses. Pregnant mice immunized with two doses of H5N1 influenza vaccine were protected from homologous infections of H5N1 influenza viruses with no viruses detected in fetuses, and that they were protected upto 30% from heterologous infections of H5N1 influenza viruses with viruses detected in fetuses. The infant mice born to mothers immunized with H5N1 influenza vaccine were fully protected from infections of H5N1 influenza viruses for upto 4 weeks of age. The protection of infant mice was closely related to the presence of IgG2a antibody in lung, heart, and rectum tissues. Our results suggest that maternal vaccination may be critical for protecting pregnant animals, their fetuses, and their infant mice from lethal infections of H5N1 influenza viruses.
高致病性 H5N1 流感病毒是下一次大流行的候选病毒之一。关于接种 H5N1 流感病毒疫苗对怀孕动物的保护性免疫的信息有限。在这里，我们表明，用灭活的 H5N1 流感疫苗对怀孕小鼠进行免疫可以保护它们、它们的胎儿和它们的幼鼠免受 H5N1 流感病毒的侵害。用两剂 H5N1 流感疫苗免疫的怀孕小鼠可以预防同源 H5N1 流感病毒的感染，胎儿中未检测到病毒，并且可以预防高达 30%的异源 H5N1 流感病毒的感染，胎儿中检测到病毒。出生于 H5N1 流感疫苗免疫母亲的幼鼠在 4 周龄之前完全免受 H5N1 流感病毒的感染。幼鼠的保护与肺部、心脏和直肠组织中 IgG2a 抗体的存在密切相关。我们的研究结果表明，母体疫苗接种可能对保护怀孕动物、它们的胎儿和它们的幼鼠免受 H5N1 流感病毒的致死性感染至关重要。
