State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Talanta. 2010 Apr 15;81(1-2):698-702. doi: 10.1016/j.talanta.2010.01.006. Epub 2010 Jan 11.
The aggregation of gold nanoparticles (GNPs) capped with nonionic fluorosurfactant (FSN) could be induced rapidly and selectively by cephradine degradation products, but not by cephradine and other excipients in pharmaceutical formulations. A new detection method for cephradine has been developed based on the cephradine degradation products-induced aggregation of the GNPs. The present approach offers various advantages, such as simplicity and high selectivity. Under optimum conditions, the lowest detectable concentration of cephradine through this approach (S/N=3) is 0.8 microg mL(-1). The calibration curve was linear over the range of 2.0-10.0 microg mL(-1) for the detection of cephradine. The recoveries of cephradine were found to fall in the range between 97% and 105%. We have validated the applicability of our method through the analyses of cephradine in pharmaceutical formulations. Good agreements were obtained for the determination of cephradine between the present approach and official method.
被非离子氟表面活性剂（FSN）覆盖的金纳米粒子（GNPs）的聚集可以被头孢菌素降解产物快速且选择性地诱导，而不是被头孢菌素和药物制剂中的其他赋形剂诱导。已经基于头孢菌素降解产物诱导的 GNPs 聚集开发了一种新的头孢菌素检测方法。该方法具有简单、高选择性等优点。在最佳条件下，通过该方法（S/N=3）检测头孢菌素的最低检测浓度为 0.8 微克/毫升（-1）。头孢菌素的检测范围为 2.0-10.0 微克/毫升（-1），校准曲线呈线性。头孢菌素的回收率在 97%至 105%之间。我们已经通过对药物制剂中头孢菌素的分析验证了我们方法的适用性。本方法与官方方法对头孢菌素的测定结果具有良好的一致性。
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