Inserm U637, Université Montpellier-2, Montpellier, France.
Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):173-7. doi: 10.1016/j.plefa.2010.02.024. Epub 2010 Feb 26.
It has been known since the 1970s that an increased consumption of n-3 long chain polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid has cardioprotective effects. Epidemiological studies have reported that this effect is due to the prevention of the arrhythmias responsible for sudden cardiac death. Mechanistically, different hypotheses have been put forward to give an explanation. Among them, there are a direct effect of the polyunsaturated fatty acids on ion channels and/or a modification of the regulation of ion channels by protein kinase C's.
自 20 世纪 70 年代以来，人们已经知道增加摄入 n-3 长链多不饱和脂肪酸，如二十碳五烯酸和二十二碳六烯酸，具有心脏保护作用。流行病学研究报告称，这种作用是由于预防了导致心源性猝死的心律失常。从机制上讲，已经提出了不同的假设来解释这一现象。其中，多不饱和脂肪酸对离子通道有直接作用，或蛋白激酶 C 对离子通道调节的修饰。
