嘌呤能信号转导与骨重建。

Purinergic signalling and bone remodelling.

机构信息

Department of Cell and Developmental Biology, University College London, London, UK.

出版信息

Curr Opin Pharmacol. 2010 Jun;10(3):322-30. doi: 10.1016/j.coph.2010.01.003. Epub 2010 Feb 25.

DOI:10.1016/j.coph.2010.01.003

PMID:20189453

Abstract

Accumulating evidence suggests that extracellular nucleotides, signalling through P2 receptors, could play an important role in modulating bone cell function. ATP and other nucleotides can stimulate the formation and resorptive activity of osteoclasts (bone-destroying cells) in addition to inhibiting bone mineralisation by osteoblasts. This review discusses the current understanding of the effects of extracellular nucleotides on skeletal cells.

摘要

越来越多的证据表明，细胞外核苷酸通过 P2 受体信号转导，可能在调节骨细胞功能方面发挥重要作用。除了抑制成骨细胞的骨矿化作用外，ATP 和其他核苷酸还可以刺激破骨细胞（骨破坏细胞）的形成和吸收活性。本文综述了细胞外核苷酸对骨骼细胞影响的最新认识。