细胞外腺苷信号在骨骼健康和疾病中的作用。
Extracellular adenosine signaling in bone health and disease.
机构信息
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27710, USA; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27710, USA; Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
出版信息
Curr Opin Pharmacol. 2023 Jun;70:102378. doi: 10.1016/j.coph.2023.102378. Epub 2023 Apr 10.
Purinergic signaling is a key molecular pathway in the maintenance of bone health and regeneration. P1 receptor signaling, which is activated by extracellular adenosine, has emerged as a key metabolic pathway that regulates bone tissue formation, function, and homeostasis. Extracellular adenosine is mainly produced by ectonucleotidases, and alterations in the function of these enzymes or compromised adenosine generation can result in bone disorders, such as osteoporosis and impaired fracture healing. This mini review discusses the key role played by adenosine in bone health and how its alterations contribute to bone diseases, as well as potential therapeutic applications of exogenous adenosine to combat bone diseases like osteoporosis and injury.
嘌呤能信号转导是维持骨骼健康和再生的关键分子途径。P1 受体信号转导被细胞外腺苷激活，已成为调节骨组织形成、功能和动态平衡的关键代谢途径。细胞外腺苷主要由核苷酸酶产生，这些酶的功能改变或腺苷生成受损可导致骨骼疾病，如骨质疏松症和骨折愈合受损。这篇迷你综述讨论了腺苷在骨骼健康中的关键作用，以及其改变如何导致骨骼疾病，以及外源性腺苷在治疗骨质疏松症和损伤等骨骼疾病方面的潜在治疗应用。
Zotero 插件