Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Campus Road, Ithaca, NY 14850, USA.
Trends Parasitol. 2010 Apr;26(4):162-7. doi: 10.1016/j.pt.2010.01.005. Epub 2010 Feb 25.
Dogs and cats are hosts to hookworms that may cause zoonotic disease, most notably, cutaneous larva migrans. Ancylostoma braziliense is most often implicated in dermatological lesions, and Ancylostoma caninum has been associated with eosinophilic enteritis and suggested as a possible cause of diffuse unilateral subacute neuroretinitis in humans. Other manifestations include eosinophilic pneumonitis, localized myositis, folliculitis, erythema multiforme, or ophthalmological manifestations. Ancylostoma eggs are morphologically indistinguishable, which complicates epidemiological studies. Surveys of dermatologists, gastroenterologists, and ophthalmologists would help to define the incidence of these zoonotic infections. Improved diagnostic tests are needed to identify the causative species involved and understand the epidemiology of hookworm disease. This review describes the discovery of the disease, the biology of the agents, and how that biology may impact disease.
狗和猫是钩虫的宿主，钩虫可能导致人畜共患病，最常见的是皮肤幼虫移行症。巴西钩口线虫最常引起皮肤病变，犬钩口线虫与嗜酸性胃肠炎有关，并被认为是人类弥漫性单侧亚急性神经视网膜炎的可能原因。其他表现包括嗜酸性肺炎、局部肌炎、毛囊炎、多形性红斑或眼部表现。钩虫卵在形态上无法区分，这使得流行病学研究变得复杂。对皮肤科医生、胃肠病学家和眼科医生进行调查将有助于确定这些人畜共患感染的发生率。需要改进诊断测试来识别相关的致病物种，并了解钩虫病的流行病学。本文综述了该病的发现、病原体的生物学特性，以及这种生物学特性如何影响疾病。
