EUS-guided cholecystoenterostomy with single-step placement of a 7F double-pigtail plastic stent in patients who are unsuitable for cholecystectomy: a pilot study (with video).

BACKGROUND

Although the definitive therapy of acute cholecystitis is cholecystectomy, nonsurgical treatment such as percutaneous cholecystostomy could be indicated in patients who are unsuitable candidates for cholecystectomy. EUS-guided cholecystoenterostomy with a plastic stent and/or nasobiliary drainage has been proposed as an alternative effective treatment for these patients.

OBJECTIVE

We conducted this study to evaluate the technical feasibility, safety, usefulness, and follow-up results of EUS-guided cholecystoenterostomy with single-step placement of a plastic stent for patients with acute cholecystitis who are unsuitable candidates for cholecystectomy.

DESIGN

A prospective feasibility study with a case series.

SETTING

Tertiary teaching hospital.

PATIENTS

Eight consecutive patients diagnosed with acute cholecystitis who were poor candidates for surgery.

INTERVENTIONS

EUS-guided cholecystoenterostomy with single-step placement of a 7F double-pigtail plastic stent.

MAIN OUTCOME MEASUREMENTS

Technical success, clinical resolution of acute cholecystitis, procedure-related complications, and recurrence of cholecystitis.

RESULTS

Technical success and clinical resolution were achieved in all patients (100% [8/8] as intent to treat). A transduodenal approach was used for 7 patients and a transgastric approach for 1 patient. One patient showed self-limited pneumoperitoneum, and bile peritonitis occurred in 1 patient. One patient showed distal stent migration without bile leakage 3 weeks after stent insertion. During follow-up periods (median 186 days; range 22-300 days), cholecystitis did not recur in any patients.

LIMITATIONS

Small number of patients.

CONCLUSION

EUS-guided cholecystoenterostomy with single-step placement of a 7F double-pigtail plastic stent may be a feasible and useful alternative in patients with acute cholecystitis who are unsuitable candidates for cholecystectomy.