Department of Diagnostic Radiology, Chung-Ang University, College of Medicine, Seoul, Republic of Korea.
Atherosclerosis. 2010 Oct;212(2):495-500. doi: 10.1016/j.atherosclerosis.2010.01.047. Epub 2010 Feb 10.
The purpose of this study was to evaluate whether the extent of epicardial adipose tissue (EAT) thickness or the presence of descending thoracic aortic calcification on multi-detector CT (MDCT) can predict the presence of significant coronary artery stenosis in patients with negative coronary artery calcium (CAC).
We enrolled 90 patients with negative CAC in whom both coronary CT angiography (CTA) and conventional angiography had been performed. Group 1 consisted of patients (n=27) with significant coronary artery stenosis (≥50%), whereas group 2 (n=63) had non-obstructive coronary artery stenosis (<50%) on conventional angiography. We analyzed whether or not there is a significant difference in EAT thickness or the incidence of calcification of descending thoracic aorta among the two groups.
There was no significant difference between EAT thickness on MDCT among the two groups. There was also no significant difference in the incidence of descending thoracic aortic calcification between group 1 (7/27, 25.9%) and group 2 (14/63, 22.2%) (p>0.05).
Neither the presence of abundant EAT nor calcification of descending thoracic aorta is a marker of significant coronary artery stenosis in patients with negative CAC.
本研究旨在评估心包外脂肪组织（EAT）厚度程度或降主动脉钙化的存在与否，能否在冠状动脉钙（CAC）阴性的患者中预测存在显著的冠状动脉狭窄。
我们纳入了 90 名 CAC 阴性的患者，他们均进行了冠状动脉 CT 血管造影（CTA）和常规血管造影检查。第 1 组为有显著冠状动脉狭窄（≥50%）的患者（n=27），而第 2 组（n=63）为常规血管造影显示非阻塞性冠状动脉狭窄（<50%）的患者。我们分析了两组患者的 EAT 厚度或降主动脉钙化的发生率是否存在显著差异。
两组患者的 MDCT 心包外脂肪组织厚度无显著差异。第 1 组（7/27，25.9%）和第 2 组（14/63，22.2%）降主动脉钙化的发生率也无显著差异（p>0.05）。
心包外脂肪组织丰富或降主动脉钙化均不是 CAC 阴性患者存在显著冠状动脉狭窄的标志物。
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