使用纤维蛋白胶联合OK-432和博来霉素对青少年鼻咽血管纤维瘤进行经皮硬化治疗。
Percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin.
作者信息
Chen Wei-liang, Huang Zhi-quan, Li Jin-song, Chai Qiang, Zhang Da-ming
机构信息
Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China.
出版信息
Int J Pediatr Otorhinolaryngol. 2010 Apr;74(4):422-5. doi: 10.1016/j.ijporl.2010.02.002. Epub 2010 Mar 1.
The purpose of this study was to determine the appropriate conditions for percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin. Three patients with juvenile nasopharyngeal angiofibroma were treated with an injection of fibrin glue combined with OK-432 and bleomycin. No major complications occurred in any of the patients. The follow-up period ranged from 12 to 14 months. The following outcomes were obtained: one lesion was completely involuted and two lesions were mostly involuted. All of the patients had normal liver and kidney function. Additionally, none of the patients presented with hematologic toxic effects or signs of pulmonary involvement. Percutaneous sclerotherapy using fibrin glue combined with OK-432 and bleomycin provided a simple, safe, and reliable alternative treatment for juvenile nasopharyngeal angiofibroma.
本研究的目的是确定使用纤维蛋白胶联合OK-432和博来霉素对青少年鼻咽血管纤维瘤进行经皮硬化治疗的合适条件。对3例青少年鼻咽血管纤维瘤患者采用纤维蛋白胶联合OK-432和博来霉素注射治疗。所有患者均未发生重大并发症。随访期为12至14个月。获得了以下结果：1个病灶完全消退，2个病灶大部分消退。所有患者的肝肾功能均正常。此外，所有患者均未出现血液学毒性作用或肺部受累迹象。使用纤维蛋白胶联合OK-432和博来霉素进行经皮硬化治疗为青少年鼻咽血管纤维瘤提供了一种简单、安全且可靠的替代治疗方法。
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