Department of Otolaryngology-Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands.
Radiother Oncol. 2010 Nov;97(2):258-62. doi: 10.1016/j.radonc.2010.02.005. Epub 2010 Feb 26.
The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy.
Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale).
Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning.
Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.
本研究调查了 80 例接受微血管重建手术和（几乎全部）辅助放疗的晚期口腔或口咽癌患者在基线和 6 个月时的健康相关生活质量（HRQOL）与生存之间的关系。
采用多变量 Cox 回归分析了总生存率和疾病特异性生存率，包括社会人口统计学（年龄、性别、婚姻状况、合并症）和临床参数（肿瘤分期和部位、根治性手术、转移、放疗），以及 HRQOL（EORTC QLQ-C30 全球生活质量量表）。
治疗前，年龄较小和有伴侣是疾病特异性生存的预测因素；年龄较小预测总体生存率。治疗后 6 个月，仅全球生活质量（恶化）预测疾病特异性和总体生存率。治疗后全球健康相关生活质量主要受情绪功能影响。
治疗后全球生活质量恶化是晚期口腔或口咽癌患者生存的独立预测因素。
