两性霉素 A 的合成及结构活性关系研究。
Zwittermicin A: synthesis of analogs and structure-activity studies.
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
出版信息
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2183-5. doi: 10.1016/j.bmcl.2010.02.032. Epub 2010 Feb 11.
Abstract
Analogs and diastereomers of the natural product zwittermicin A were prepared. SAR studies of these compounds reveal the antifungal activity to be dependent singularly upon the natural constitution and configuration.
摘要
天然产物两性霉素 A 的类似物和非对映异构体被制备。这些化合物的 SAR 研究表明，其抗真菌活性仅取决于天然结构和构型。
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