Translational Medicine Research Collaboration, Ninewells Hospital and Medical School, Dundee, UK.
Mol Genet Metab. 2010;100 Suppl 1:S92-6. doi: 10.1016/j.ymgme.2010.01.010. Epub 2010 Jan 29.
Drug discovery and development has evolved significantly over the last century. Extrapolation from current practice invites speculation about the future in four areas of particular interest. These include the range of therapeutic modalities; the methods for selection of drug targets; the interjection of translational medicine in between the traditional discovery and development phases; and the relationships between institutions. A major focus for the latter three developments is the shortcomings of current target validation. This personal view will be given from perspectives gained in large integrated pharmaceutical companies that are primarily focused on common disorders. Where appropriate, comparisons will be made to the development of treatments for rare Mendelian disorders.
药物研发在过去一个世纪发生了重大变革。从当前的实践推断，有四个特别引人关注的领域的未来发展值得猜测。这些领域包括治疗方式的范围；药物靶点选择的方法；将转化医学引入传统的发现和开发阶段之间；以及机构之间的关系。后三个发展的主要重点是当前目标验证的缺点。这篇个人观点将从主要关注常见疾病的大型综合制药公司获得的角度给出。在适当的情况下，将与罕见孟德尔疾病治疗方法的发展进行比较。
