De Luis Daniel A, González Sagrado Manuel, Aller Rocío, Izaola Olatz, Conde Rosa, Romero Enrique
Instituto de Endocrinología y Nutrición, Unidad de Investigación, Facultad de Medicina, Hospital Río Hortega, Universidad de Valladolid (RETICEF 056/0013), Valladolid, Spain.
Endocrinol Nutr. 2010 Feb;57(2):54-9. doi: 10.1016/j.endonu.2010.01.001. Epub 2010 Mar 1.
The 385 C/A polymorphism of fatty acid amide hydrolase (FAAH) has recently been demonstrated to be associated with overweight and obesity. The aim of our study was to investigate the association between missense polymorphism (cDNA 385 C->A) of the FAAH gene and anthropometric parameters, cardiovascular risk factors and adipocytokines in morbidly obese patients.
A sample of 66 morbidly obese patients was analyzed. In all patients, weight, blood pressure, fasting glycemia, lipoprotein(a), C-reactive protein, insulin, total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglyceride and adipocytokine levels, as well as the genotype of the C358A polymorphism of FAAH, were determined.
The mean age was 48.0(16.1) years and the mean body mass index was 44.4 (4.1). There were 17 males (25.8%) and 49 females (74.2%). Forty-five patients (8 males/37 females) (68.2%) were G358G (wild genotype) and 21 patients (4 males/17 females) were G358A (31.8%) (mutant group). Biochemical, anthropometrical and adipocytokine levels showed no statistically significant differences between the two genotypes.
In patients with morbid obesity, the C358A polymorphism of FAAH was not associated with anthropometric parameters, biochemical markers or adipocytokine levels.
脂肪酸酰胺水解酶（FAAH）的385 C/A多态性最近被证明与超重和肥胖有关。我们研究的目的是调查FAAH基因错义多态性（cDNA 385 C->A）与病态肥胖患者的人体测量参数、心血管危险因素和脂肪细胞因子之间的关联。
分析了66例病态肥胖患者的样本。测定了所有患者的体重、血压、空腹血糖、脂蛋白（a）、C反应蛋白、胰岛素、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯和脂肪细胞因子水平，以及FAAH基因C358A多态性的基因型。
平均年龄为48.0（16.1）岁，平均体重指数为44.4（4.1）。有17名男性（25.8%）和49名女性（74.2%）。45例患者（8名男性/37名女性）（68.2%）为G358G（野生基因型），21例患者（4名男性/17名女性）为G358A（31.8%）（突变组）。两种基因型之间的生化、人体测量和脂肪细胞因子水平无统计学显著差异。
在病态肥胖患者中，FAAH基因的C358A多态性与人体测量参数、生化标志物或脂肪细胞因子水平无关。
