Center of investigation of Endocrinology and Clinical Nutrition, University of Valladolid Medical School and Unit of Investigation, Hospital Rio Hortega, Valladolid, Spain.
Surg Obes Relat Dis. 2010 Sep-Oct;6(5):516-20. doi: 10.1016/j.soard.2010.01.005. Epub 2010 Feb 6.
Bariatric surgery is the most effective long-term treatment of morbid obesity and also results in a reduction of obesity-associated co-morbidities. We investigated the role of the polymorphism (C358A) of the fatty acid amide hydrolase gene on the clinical outcomes 1 year after biliopancreatic diversion in morbidly obese patients.
A total of 67 morbidly obese patients (body mass index >40 kg/m(2)) underwent biliopancreatic diversion. Their weight, blood pressure, basal glucose, triglycerides, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were measured at the baseline visit and at each follow-up visit. The frequency of the metabolic co-morbidities was recorded at each visit.
Of the 67 patients, 46 (68.7%) had genotype C358C (wild-type group) and 21 (10.3%) had genotype C358A (mutant-type group). In the wild- and mutant-type groups, the body mass index, weight, waist circumference, systolic blood pressure, and glucose, total cholesterol, low-density lipoprotein cholesterol, and triglyceride concentrations decreased, without statistical significance between the 2 groups. The initial percentage of weight loss at 9 months and 1 year of follow-up was greater in the mutant-type group (9 months, 22.1% versus 28.8%, P <.05; and 1 year, 28.3% versus 36.4%, P <.05).
The allele A358 of fatty acid amide hydrolase was associated with a better initial percentage of excess weight loss 9 and 12 months after biliopancreatic diversion.
减重手术是治疗病态肥胖最有效的长期方法，也可降低肥胖相关合并症。我们研究了脂肪酸酰胺水解酶基因（C358A）多态性在病态肥胖患者行胆胰分流术后 1 年的临床结果中的作用。
共 67 例病态肥胖患者（BMI＞40kg/m2）接受胆胰分流术。在基线访视和每次随访时测量体重、血压、基础血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇。每次访视时记录代谢合并症的发生频率。
在 67 例患者中，46 例（68.7%）基因型为 C358C（野生型组），21 例（10.3%）基因型为 C358A（突变型组）。在野生型和突变型组中，体重指数、体重、腰围、收缩压和血糖、总胆固醇、低密度脂蛋白胆固醇和甘油三酯浓度降低，但两组间无统计学差异。突变型组术后 9 个月和 1 年的初始体重减轻百分比更高（9 个月时，22.1%比 28.8%，P＜.05；1 年时，28.3%比 36.4%，P＜.05）。
脂肪酸酰胺水解酶的等位基因 A358 与胆胰分流术后 9 和 12 个月时超重减轻的初始百分比更好相关。
