Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA.
Psychosom Med. 2010 May;72(4):333-9. doi: 10.1097/PSY.0b013e3181d2f104. Epub 2010 Feb 26.
To examine the effects of depressive symptoms and hostility on changes in C-reactive protein (CRP) and interleukin (IL)-6 in response to an acute laboratory stressor. Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6.
The study included 307 men and 218 women, affording the opportunity to examine moderation by gender. Regression analyses were performed to examine depressive symptoms, hostility ratings, gender, and their interactions as predictors of CRP and IL-6 response to an emotion recall task. Analyses were adjusted for age, race, body mass index, and prerecall task levels of either CRP or IL-6.
The product term for Depressive Symptoms x Hostility x Gender was not significantly related to CRP nor IL-6 response. However, Depressive Symptoms x Hostility did interact to predict CRP response (p = .002); those with the combination of high symptoms of depression and hostility had the largest CRP response. The Depressive Symptoms x Gender interaction was also a predictor of both CRP (p = .001) and IL-6 (p = .04) response; for each inflammatory marker, depressive symptoms were significantly associated with higher CRP response in women, as compared with men. Hostility did not moderate depressive symptoms, nor gender for IL-6.
Our findings extend prior research by suggesting that, broadly speaking, depression is related to inflammatory markers; however, this relationship seems complex. Depression seems to be related to inflammation more strongly among hostile individuals and more strongly among women than among men.
探讨抑郁症状和敌意对 C 反应蛋白（CRP）和白细胞介素（IL）-6 对急性实验室应激反应变化的影响。抑郁症状调节特质敌意对 CRP 和 IL-6 循环水平的影响。
该研究包括 307 名男性和 218 名女性，有机会通过性别检验调节作用。采用回归分析检验抑郁症状、敌意评分、性别及其相互作用作为情绪回忆任务对 CRP 和 IL-6 反应的预测因子。分析调整了年龄、种族、体重指数和 CRP 或 IL-6 的预回忆任务水平。
抑郁症状×敌意×性别乘积项与 CRP 或 IL-6 反应均无显著相关。然而，抑郁症状×敌意确实相互作用预测 CRP 反应（p =.002）；具有高抑郁症状和敌意的组合的人 CRP 反应最大。抑郁症状×性别相互作用也是 CRP（p =.001）和 IL-6（p =.04）反应的预测因素；对于每个炎症标志物，与男性相比，抑郁症状与女性 CRP 反应更高显著相关。敌意并没有调节抑郁症状，也没有调节性别对 IL-6 的影响。
我们的发现扩展了先前的研究，表明抑郁广泛地与炎症标志物有关；然而，这种关系似乎很复杂。与不具有敌意的个体相比，具有敌意的个体中抑郁与炎症的关系更为密切，而女性比男性更为密切。
