Graham Eileen K, Bastarache Emily D, Milad Elizabeth, Turiano Nicholas A, Cotter Kelly A, Mroczek Daniel K
Department of Psychology, Weinberg College of Arts & Sciences, Northwestern University, Evanston, IL, USA.
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
SAGE Open Med. 2018 May 15;6:2050312118774990. doi: 10.1177/2050312118774990. eCollection 2018.
The current study investigated whether personality traits and facets were associated with interleukin-6, C-reactive protein, and fibrinogen, and whether physical activity mediated the relationship between personality and biomarkers of inflammation.
Personality was assessed in the Midlife Development in the United States study using the Multi-Dimensional Personality Questionnaire and Midlife Development Inventory personality scale. Data were included from 960 participants (mean age = 57.86 years, standard deviation = 11.46). Personality was assessed from 2004 to 2009. Serum levels of interleukin-6, fibrinogen, and C-reactive protein were assessed in 2005-2009 as part of the Midlife Development in the United States biomarkers subproject.
Lower neuroticism was associated with elevated interleukin-6, and achievement was associated with lower fibrinogen. Higher physical activity was associated with lower interleukin-6 and C-reactive protein. Mediation models suggested that physical activity mediated the associations between achievement and both interleukin-6 and C-reactive protein.
Physical activity is an important factor in the Health Behavior Model of personality and explains some of the associations between personality and inflammation. These findings contribute to the fields of aging and health by linking individual difference factors to markers of inflammation, and showing that these processes may function partially through specific behaviors, in this case physical activity.
本研究调查了人格特质及相关方面是否与白细胞介素-6、C反应蛋白和纤维蛋白原相关，以及体育活动是否介导了人格与炎症生物标志物之间的关系。
在美国中年发展研究中，使用多维人格问卷和中年发展量表对人格进行评估。数据来自960名参与者（平均年龄=57.86岁，标准差=11.46）。人格评估时间为2004年至2009年。作为美国中年发展生物标志物子项目的一部分，于2005年至2009年评估了白细胞介素-6、纤维蛋白原和C反应蛋白的血清水平。
较低的神经质与较高的白细胞介素-6相关，成就感与较低的纤维蛋白原相关。较高的体育活动与较低的白细胞介素-6和C反应蛋白相关。中介模型表明，体育活动介导了成就感与白细胞介素-6和C反应蛋白之间的关联。
体育活动是人格健康行为模型中的一个重要因素，并解释了人格与炎症之间的一些关联。这些发现通过将个体差异因素与炎症标志物联系起来，并表明这些过程可能部分通过特定行为（在本研究中为体育活动）发挥作用，为衰老和健康领域做出了贡献。
