Qin Y X, Lam H, Ferreri S, Rubin C
Orthopaedic Bioengineering Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794-5281, USA.
J Musculoskelet Neuronal Interact. 2010 Mar;10(1):12-24.
To identify mechanotransductive signals for combating musculoskeletal deterioration, it is essential to determine the components and mechanisms critical to the anabolic processes of musculoskeletal tissues. It is hypothesized that the interaction between bone and muscle may depend on fluid exchange in these tissues by mechanical loading. It has been shown that intramedullary pressure (ImP) and low-level bone strain induced by muscle stimulation (MS) has the potential to mitigate bone loss induced by disuse osteopenia. Optimized MS signals, i.e., low-intensity and high frequency, may be critical in maintaining bone mass and mitigating muscle atrophy. The objectives for this review are to discuss the potential for MS to induce ImP and strains on bone, to regulate bone adaptation, and to identify optimized stimulation frequency in the loading regimen. The potential for MS to regulate blood and fluid flow will also be discussed. The results suggest that oscillatory MS regulates fluid dynamics with minimal mechanical strain in bone. The response was shown to be dependent on loading frequency, serving as a critical mediator in mitigating bone loss. A specific regimen of dynamic MS may be optimized in vivo to attenuate disuse osteopenia and serve as a biomechanical intervention in the clinical setting.
为了确定对抗肌肉骨骼退化的机械转导信号，确定对肌肉骨骼组织合成代谢过程至关重要的成分和机制至关重要。据推测，骨骼与肌肉之间的相互作用可能取决于机械负荷作用下这些组织中的液体交换。研究表明，髓内压（ImP）和肌肉刺激（MS）引起的低水平骨应变有可能减轻废用性骨质减少引起的骨质流失。优化后的MS信号，即低强度和高频信号，可能对维持骨量和减轻肌肉萎缩至关重要。本综述旨在探讨MS在骨骼上诱导ImP和应变、调节骨适应性以及确定加载方案中最佳刺激频率的潜力。还将讨论MS调节血液和液体流动的潜力。结果表明，振荡性MS以骨骼中最小机械应变调节流体动力学。研究显示该反应取决于加载频率，并在减轻骨质流失中起关键调节作用。动态MS的特定方案可能在体内得到优化，以减轻废用性骨质减少，并在临床环境中作为一种生物力学干预措施。
