Liu R, Schindeler A, Little D G
Department of Orthopaedic Research and Biotechnology, the Children's Hospital at Westmead, Sydney, Australia.
J Musculoskelet Neuronal Interact. 2010 Mar;10(1):71-6.
Bone repair is a complex phenomenon involving many cell types and signaling factors. Substantial evidence exists to suggest that stem cells originating from local osseous tissues, particularly the periosteum, can contribute to bone repair. However, there are situations where injury or post-surgical management can deplete the amount of, and/or access to these crucial progenitors. The fact that bone repair can still occur in these circumstances implicitly reflects the existence of compensatory secondary systems. One potential alternate source of osteoprogenitors is muscle, which is closely associated with bone and typically suffers trauma during an orthopedic insult. While muscle access is known to be beneficial to bone repair, this is conventionally credited to its high vascularity, and thus its contribution to the local blood supply. However, there is emerging evidence to suggest that progenitors from muscle may directly contribute to bone healing. Defining the role of muscle in bone formation and repair has significant clinical implications, particularly where promoting access to this tissue may enhance the repair outcome.
骨修复是一个涉及多种细胞类型和信号因子的复杂现象。大量证据表明，源自局部骨组织，特别是骨膜的干细胞可促进骨修复。然而，在某些情况下，损伤或术后处理可能会耗尽这些关键祖细胞的数量和/或获取途径。在这些情况下骨修复仍能发生这一事实隐含地反映了代偿性二级系统的存在。骨祖细胞的一个潜在替代来源是肌肉，它与骨紧密相连，在骨科损伤中通常会受到创伤。虽然已知肌肉的接入对骨修复有益，但传统上这归功于其高血管化，因此其对局部血液供应的贡献。然而，越来越多的证据表明，来自肌肉的祖细胞可能直接促进骨愈合。确定肌肉在骨形成和修复中的作用具有重要的临床意义，特别是在促进对该组织的接入可能会提高修复结果的情况下。
