Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, USA.
MAbs. 2010 Mar-Apr;2(2):165-75. doi: 10.4161/mabs.2.2.11360.
Angiogenesis is required in normal physiological processes, but is also involved in tumor growth, progression and metastasis. Vascular endothelial growth factor (VEGF), a primary mediator of angiogenesis in normal physiology and in disease, and other VEGF family members and their receptors provide targets that have been explored extensively for cancer therapy. Small molecule inhibitors and antibody/protein-based strategies that target the VEGF pathway have been studied in multiple types of cancer. This review will focus on VEGF pathway targeting antibodies that are currently being evaluated in pre-clinical and clinical studies.
血管生成在正常生理过程中是必需的,但也参与肿瘤的生长、进展和转移。血管内皮生长因子(VEGF)是正常生理和疾病中血管生成的主要介质,以及其他 VEGF 家族成员及其受体为癌症治疗提供了广泛探索的靶点。针对 VEGF 通路的小分子抑制剂和抗体/蛋白策略已在多种类型的癌症中进行了研究。本文综述重点介绍了目前正在临床前和临床研究中评估的针对 VEGF 通路的靶向抗体。