Division of Clinical Research and Occupational Medicine, Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
J Occup Environ Med. 2010 Mar;52(3):324-31. doi: 10.1097/JOM.0b013e3181d241fa.
To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes.
Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure.
Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV.
This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.
初步制定方案以评估交通空气中的污染物对车内糖尿病患者心血管的急性影响。
21 名 2 型糖尿病志愿者乘坐汽车在繁忙的高速公路上行驶 90-110 分钟。我们测量了车内的颗粒物数量和质量（PM2.5）、二氧化氮、一氧化碳和心率、心率变异性（HRV）和血压。
与乘车前测量值相比，我们发现乘车后次日高频 HRV 下降（比值 0.66，95%置信区间为 0.47 至 0.93），低频到高频比值增加（比值 1.92，95%置信区间为 1.21 至 3.05）。乘车后测量的污染物中四分位间距的增加与次日 HRV 下降有关。
本方案似乎可用于评估车内接触交通空气污染物对糖尿病患者的急性不良心血管影响。
