糖尿病患者在高速公路交通暴露后心率变异性的急性变化。
Acute changes in heart rate variability in subjects with diabetes following a highway traffic exposure.
机构信息
Division of Clinical Research and Occupational Medicine, Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
出版信息
J Occup Environ Med. 2010 Mar;52(3):324-31. doi: 10.1097/JOM.0b013e3181d241fa.
Abstract
OBJECTIVE
To pilot a protocol to evaluate acute cardiovascular effects in in-vehicle exposure to traffic air pollutants in people with diabetes.
METHODS
Twenty-one volunteers with type 2 diabetes were passengers on 90- to 110-minute car rides on a busy highway. We measured in-vehicle particle number and mass (PM2.5) nitrogen dioxide, and carbon monoxide and heart rate, heart rate variability (HRV), and blood pressure.
RESULTS
Compared with pre-ride measurements, we found a decrease in high frequency (HF) HRV from pre-ride to next day (ratio 0.66, 95% CI = 0.47 to 0.93) and an increase in low frequency to HF ratio at post-ride (ratio 1.92, 95% CI = 1.21 to 3.05) at post-ride. Interquartile range increases in measured pollutants were associated with next-day decreases in HR HRV.
CONCLUSIONS
This protocol appears useful for assessing acute adverse cardiovascular effects of in-vehicle exposures among people who have diabetes.
摘要
目的
初步制定方案以评估交通空气中的污染物对车内糖尿病患者心血管的急性影响。
方法
21 名 2 型糖尿病志愿者乘坐汽车在繁忙的高速公路上行驶 90-110 分钟。我们测量了车内的颗粒物数量和质量（PM2.5）、二氧化氮、一氧化碳和心率、心率变异性（HRV）和血压。
结果
与乘车前测量值相比，我们发现乘车后次日高频 HRV 下降（比值 0.66，95%置信区间为 0.47 至 0.93），低频到高频比值增加（比值 1.92，95%置信区间为 1.21 至 3.05）。乘车后测量的污染物中四分位间距的增加与次日 HRV 下降有关。
结论
本方案似乎可用于评估车内接触交通空气污染物对糖尿病患者的急性不良心血管影响。
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本文引用的文献
1
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Epidemiology. 2009 Mar;20(2):265-71. doi: 10.1097/EDE.0b013e318190ea68.
2
Endothelial dysfunction: associations with exposure to ambient fine particles in diabetic individuals.内皮功能障碍：糖尿病个体暴露于环境细颗粒物中的相关性。
Environ Health Perspect. 2008 Dec;116(12):1666-74. doi: 10.1289/ehp.11666. Epub 2008 Jul 31.
3
Diesel exhaust inhalation elicits acute vasoconstriction in vivo.吸入柴油机废气会在体内引发急性血管收缩。
Environ Health Perspect. 2008 Jul;116(7):937-42. doi: 10.1289/ehp.11027.
4
Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-ethnic Study of Atherosclerosis (MESA).动脉粥样硬化多族裔研究（MESA）中近期暴露于环境细颗粒物与血压之间的关联。
Environ Health Perspect. 2008 Apr;116(4):486-91. doi: 10.1289/ehp.10899.
5
Respiratory effects of exposure to diesel traffic in persons with asthma.哮喘患者暴露于柴油尾气中的呼吸影响。
N Engl J Med. 2007 Dec 6;357(23):2348-58. doi: 10.1056/NEJMoa071535.
6
Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis.氧化应激诱导的与代谢综合征相关的危险因素：一个统一的假说。
J Nutr Biochem. 2008 Aug;19(8):491-504. doi: 10.1016/j.jnutbio.2007.06.011. Epub 2007 Sep 12.
7
In-cabin commuter exposure to ultrafine particles on Los Angeles freeways.洛杉矶高速公路上车内通勤者接触超细颗粒物的情况。
Environ Sci Technol. 2007 Apr 1;41(7):2138-45. doi: 10.1021/es0618797.
8
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9
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Res Rep Health Eff Inst. 2005 Jun(124):83-126; discussion 127-48.
10
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Res Rep Health Eff Inst. 2005 Jun(124):1-66; discussion 67-82, 141-8.
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