成功根除幽门螺杆菌感染 1 年后的复发：伊朗北部的一项前瞻性研究。

Recurrence of Helicobacter pylori infection 1 year after successful eradication: a prospective study in Northern Iran.

机构信息

Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Razi Hospital, Sardar-jangle Ave., P.O. box 41448-95655, Rasht, Iran.

出版信息

Med Sci Monit. 2010 Mar;16(3):CR144-148.

PMID:20190685

Abstract

BACKGROUND

The aim was to investigate the H. pylori recurrence rate one year after successful eradication in dyspeptic patients in Guilan province, northern Iran.

MATERIAL/METHODS: Patients with chronic dyspepsia were enrolled in our gastroenterology clinic. Gastric biopsies were obtained by endoscopy and H. pylori infection was diagnosed using the Rapid Urease Test (RUT). Patients with H. pylori infection were prescribed clarithromycine-based quadruple therapy for 10 days. The (13)C urea breath test ((13)C-UBT) was used to assess H. pylori status 10 weeks after completing H. pylori therapy. Patients who H. pylori-negative had a second (13)C-UBT after 1 year to establish the recurrence rate.

RESULTS

Of 269 dyspeptic patients with RUT positivity for H. pylori in endoscopy who were treated with the quadruple regimen for 10 days, 240 had negative (13)C-UBT 10 weeks after the end of therapy, with an eradication rate of 89.2% (95%CI: 82.2-97.2%) by per-protocol analysis. Of this group, 153 patients (63.8%) were female. The (13)C-UBT at 1 year was positive in 12 (5.0%) of the 240 patients. A mean age of >35 year, being female, living in an urban area, and a household size of more than 5 person were more frequent in the (13)C-UBT-positive patients at 1 year, but they were not statistically significant. In this study there was also no significant relationship between, job, educational status, and the source of domestic water with recurrence of H. pylori infection.

CONCLUSIONS

According to these data, the H. pylori recurrence rate in our region is 5% after successful eradication.

摘要

背景

本研究旨在调查伊朗北部吉兰省消化不良患者成功根除幽门螺杆菌（H. pylori）后一年的复发率。

材料/方法：在我们的胃肠病诊所招募了患有慢性消化不良的患者。通过内镜获取胃活检，使用快速尿素酶试验（RUT）诊断 H. pylori 感染。患有 H. pylori 感染的患者接受了为期 10 天的克拉霉素为基础的四联疗法。在完成 H. pylori 治疗后 10 周，使用（13）C 尿素呼气试验（（13）C-UBT）评估 H. pylori 状态。H. pylori 阴性的患者在 1 年后进行第二次（13）C-UBT，以确定复发率。

结果

在接受为期 10 天四联方案治疗的 269 例内镜检查中 RUT 阳性的消化不良患者中，240 例患者在治疗结束后 10 周（13）C-UBT 阴性，根除率为 89.2%（95%CI：82.2-97.2%），根据方案分析。该组中有 153 名患者（63.8%）为女性。在 240 例患者中，有 12 例（5.0%）在 1 年时（13）C-UBT 阳性。在 1 年时（13）C-UBT 阳性的患者中，年龄大于 35 岁、女性、居住在城市地区以及家庭人口超过 5 人更为常见，但无统计学意义。在这项研究中，工作、教育程度和家庭用水来源与 H. pylori 感染的复发也没有显著关系。