中国南方沿海地区幽门螺杆菌感染成功根除后的复发率及影响因素

Recurrence Rate and Influencing Factors of Helicobacter Pylori Infection After Successful Eradication in Southern Coastal China.

作者信息

Zhang Daya, Mao Fengjiao, Huang Shimei, Chen Chen, Li Da, Zeng Fan, Bai Feihu

机构信息

Graduate School, Hainan Medical University, Haikou, People's Republic of China.

Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, People's Republic of China.

出版信息

Int J Gen Med. 2024 Mar 19;17:1039-1046. doi: 10.2147/IJGM.S452348. eCollection 2024.

DOI:10.2147/IJGM.S452348

PMID:38529098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10961585/

Abstract

PURPOSE

Recurrence rate of Helicobacter pylori () infection after successful eradication have gained attention. This study was to assess the recurrence rate of infection after successful eradication in the southern coastal provinces of China and to analyze its factors.

PATIENTS AND METHODS

975 patients with upper gastrointestinal symptoms who were diagnosed with using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022. After eight to twelve weeks, repeat UBT was performed. Besides, 824 patients with successful eradication underwent a repeat UBT by completing questionnaires after a year. The 1-year recurrence rate was calculated, and the differences were analyzed based on baseline data, sociological characteristics, and lifestyle.

RESULTS

A total of 734 patients completed the 1-year follow-up, out of which 26 (3.5%) patients experienced a recurrence of infection. Exposure to other individuals infected with (=12.852, <0.001), poor hygiene conditions at dining out places (=6.839, =0.009), frequent dining out (=24.315, <0.001), smoking (=7.510, =0.006), consumption of non-purified water (=16.437, <0.001), consumption of pickled foods (=5.682, =0.017), irregular meal patterns (=16.877, <0.001) and age (=9.195, P=0.010) were significant factors for infection recurrence. Exposure to other individuals infected with , poor hygiene conditions at dining out places, consumption of non-purified water, frequent dining out and irregular meal patterns were independent risk factors (=0.022, 0.016, 0.002, <0.001, <0.001; 95% CI 0.146-0.861, 0.121-0.806, 1.715-10.845, 0.085-0.521, 2.291-14.556).

CONCLUSION

The one-year recurrence rate of infection post-eradication in the southern coastal provinces of China is 3.5%. Contacting with infected individuals, poor hygiene in dining places, consumption of non-purified water, frequent dining out, and irregular meal patterns were identified as significant independent factors influencing recurrence.

摘要

目的

幽门螺杆菌（Hp）感染成功根除后的复发率已受到关注。本研究旨在评估中国南部沿海省份Hp感染成功根除后的复发率，并分析其相关因素。

患者与方法

2021年8月至2022年12月期间，975例有上消化道症状且经13C或14C尿素呼气试验（UBT）诊断为Hp感染的患者接受了根除治疗。八至十二周后，进行重复UBT。此外，824例根除成功的患者在一年后通过填写问卷进行了重复UBT。计算1年复发率，并根据基线数据、社会学特征和生活方式分析差异。

结果

共有734例患者完成了1年随访，其中26例（3.5%）患者出现Hp感染复发。接触其他Hp感染个体（P = 12.852，P < 0.001）、外出就餐场所卫生条件差（P = 6.839，P = 0.009）、频繁外出就餐（P = 24.315，P < 0.001）、吸烟（P = 7.510，P = 0.006）、饮用非纯净水（P = 16.437，P < 0.001）、食用腌制食品（P = 5.682，P = 0.017）、饮食不规律（P = 16.877，P < 0.001）和年龄（P = 9.195，P = 0.010）是Hp感染复发的显著因素。接触其他Hp感染个体、外出就餐场所卫生条件差、饮用非纯净水、频繁外出就餐和饮食不规律是独立危险因素（P = 0.022，0.016，0.002，P < 0.001，P < 0.001；95%可信区间0.146 - 0.861，0.121 - 0.806，1.715 - 10.845，0.085 - 0.521，2.291 - 14.556）。