甲状旁腺激素与 TGF-β在骨骼中相互作用。
PTH battles TGF-beta in bone.
机构信息
NSERM UMRS 938, Hôpital St-Antoine, 184 Rue du Faubourg St-Antoine, 75571, Paris, France.
出版信息
Nat Cell Biol. 2010 Mar;12(3):205-7. doi: 10.1038/ncb0310-205.
PMID:20190828
Abstract
Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-beta). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.
摘要
脊椎动物的骨骼重塑是由甲状旁腺激素 (PTH) 和转化生长因子-β (TGF-β) 的相反作用协调调节的。PTH 通过强制内化 TGF-β 型 II 受体 (TβRII) 和 PTH 型 1 受体 (PTH1R) 来耦联骨吸收和形成过程，从而减弱体内 TGF-β 和 PTH 信号传导。
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