沙特阿拉伯接受角膜移植手术患者中的角膜营养不良

Corneal dystrophies among patients undergoing keratoplasty in Saudi Arabia.

作者信息

al Faran M F, Tabbara K F

机构信息

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Cornea. 1991 Jan;10(1):13-6.

PMID:2019101

Abstract

Diseases leading to corneal opacities are inflammations, infections, metabolic causes, trauma, or genetically determined diseases. Corneal dystrophies may lead to corneal blindness. A clinical and pathological review of 2,108 corneal specimens received from December 1983 to January 1988 revealed 86 (4%) corneal specimens with corneal dystrophies. Fifty-three (62%) patients had macular dystrophy, 11 (13%) had congenital hereditary endothelial dystrophy (CHED), 12 (14%) had Fuchs' corneal dystrophy, 5 (6%) had lattice corneal dystrophy, and 3 (4%) had granular dystrophy. Macular dystrophy appears to be the most common cause of corneal dystrophy in Saudi Arabia. Twenty-two (42%) patients with macular dystrophy and 10 (91%) patients with CHED were the result of consanguineous marriages. Genetic counseling is advisable among families who carry the trait of CHED or macular corneal dystrophy.

摘要

导致角膜混浊的疾病包括炎症、感染、代谢原因、外伤或遗传性疾病。角膜营养不良可能导致角膜盲。对1983年12月至1988年1月收到的2108份角膜标本进行的临床和病理检查显示，有86份（4%）角膜标本存在角膜营养不良。53例（62%）患者患有斑点状营养不良，11例（13%）患有先天性遗传性内皮营养不良（CHED），12例（14%）患有富克斯角膜营养不良，5例（6%）患有格子状角膜营养不良，3例（4%）患有颗粒状营养不良。斑点状营养不良似乎是沙特阿拉伯角膜营养不良最常见的原因。22例（42%）斑点状营养不良患者和10例（91%）CHED患者是近亲结婚的结果。对于携带CHED或斑点状角膜营养不良特征的家庭，建议进行遗传咨询。