KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia.
ChemSusChem. 2010 May 25;3(5):502-22. doi: 10.1002/cssc.200900221.
Carbon-carbon cross-coupling reactions are among the most important processes in organic chemistry, and Suzuki-Miyaura reactions are among the most widely used protocols for the formation of carbon-carbon bonds. These reactions are generally catalyzed by soluble palladium complexes with various ligands. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance. This Review will summarize various recently developed significant methods by which the Suzuki-Miyaura coupling was conducted in aqueous media, and analyzes if they are "real green" protocols.
碳-碳交叉偶联反应是有机化学中最重要的反应之一，而铃木-宫浦反应则是形成碳-碳键最广泛使用的方法之一。这些反应通常由各种配体的可溶性钯配合物催化。然而，使用有毒有机溶剂仍然是一个科学挑战，也是经济和生态方面的一个重要问题。本文综述了近年来在水相介质中进行铃木-宫浦偶联反应的各种有意义的方法，并分析它们是否是“真正的绿色”方法。
