Matei Mioara, Negură L, Carasevici E, Azoicăi Doina
Disciplina de Asistenţa Primară a Stării de Sănătate si Epidemiologie, Facultateă de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2009 Oct-Dec;113(4):1216-21.
Genital cancers represent an important issue regarding women health, as they produce a large number of cases, invalidities and deaths.
The evaluation of individual risks for a group of women with genital neoplasia.
We conducted a pilot case-control study to validate the questionnaire for the evaluation of risk factors in genital cancers, in a number of 40 female subjects (20 cases and 20 controls). We have realized the data processing using the SPSS 16 and EpiInfo 3.5.1. soft wares.
For questionnaire validation we have evaluated the reproducibility, the validity, the acceptability and the practicability of the questionnaire. In order to establish the test reproducibility, we have calculated k factors for inter-investigator (k = 0.34) and intra-investigator (k = 0.72) variation. To evaluate the questionnaire validity we calculated the sensitivity (cases = 94%; controls = 97%), specificity (cases = 67%, controls = 75%), positive predictive value (cases = 94%; controls = 94%), negative predictive value (cases = 67%; controls = 86%). The risk factors most frequently identified were genital infectious in clinical records (75% comparing to 52.5% - p = 0.036), and also the presence of other pathological records in genital area (65% comparing to 22.5% - p = 0.0001).
For an accurate identification of individual risk at women with genital cancers subsequently studies on greater number of subjects is necessary.
生殖系统癌症是女性健康的一个重要问题，因为这类癌症导致大量病例、残疾和死亡。
评估一组患有生殖系统肿瘤的女性的个体风险。
我们进行了一项病例对照试点研究，以验证用于评估生殖系统癌症风险因素的问卷，研究对象为40名女性受试者（20例病例和20名对照）。我们使用SPSS 16和EpiInfo 3.5.1软件进行数据处理。
为了验证问卷，我们评估了问卷的可重复性、有效性、可接受性和实用性。为了确定测试的可重复性，我们计算了调查员间（k = 0.34）和调查员内（k = 0.72）变异的k系数。为了评估问卷的有效性，我们计算了敏感度（病例组 = 94%；对照组 = 97%）、特异度（病例组 = 67%，对照组 = 75%）、阳性预测值（病例组 = 94%；对照组 = 94%）、阴性预测值（病例组 = 67%；对照组 = 86%）。最常确定的风险因素是临床记录中的生殖系统感染（75% 对比52.5% - p = 0.036），以及生殖系统区域存在其他病理记录（65% 对比22.5% - p = 0.0001）。
为了准确识别患有生殖系统癌症女性的个体风险，有必要对更多受试者进行后续研究。
