Matei Mioara, Olteanu St, Ciolpan Corina, Azoicăi Doina
Facultatea de Medicină, Disciplina de Asistenţa Primară a Stării de Sănătate si Epidemiologie, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Rev Med Chir Soc Med Nat Iasi. 2008 Jul-Sep;112(3):775-85.
The genitals and breast cancers takes an important place in the women's pathology, either through the increase numbers of cases and also through the mortality induced by these cases.
The descriptive evaluation of the genitals and breast cancers and there risk factors to women from North-Eastern region of Romania.
We have been included in the study 105 women (age range 23-77 years, mean 53,77) diagnosed with breast cancer, ovarian cancer, endometrial cancer and cervical cancer at the hospital admission, residency in the "Cuza Vodă" Iaşi Hospital--Obstetrics and Gynecology Clinic (I, II, and IV Gynecologic Clinics) and "Elena Doamna" Iaşi Hospital--Obstetrics and Gynecology Clinic (III Gynecologic Clinics) within 11 months. We have used a special questionnaire for the evaluation of the risk factors. Trained interviewers identified and questioned cases. The following parameters were assessed: marital status, educational level, age at menarche, age at the first sexual contact, age at first birth, parity, spontaneous abortions, period of breast-feeding, menopausal status, age at menopause, family history of cancers, personal history of gynecologic diseases, body mass index, oral contraceptive use, hormone replacement therapy use, environmental exposures, Pap test. After data collection, these have been codified and included in a MS Excel Database, in order to be processed with SPSS 13 and EpiInfo 3.4.3. (2007) softwares.
The following cases' repartition on diagnostic types was observed: breast cancer (41 cases), cervical cancer (24 cases), endometrial cancer (12 cases) and ovarian cancer (7 cases). The cases mean of age was 56.22 years for breast cancer, 46.29 for cervical cancer, 59.75 for endometrial cancer and 54.86 for ovarian cancer. In our study, the most affected range of age was 50-59 years for breast cancer (p = 0,00033), 40-49 years for cervical cancer (p = 0,00257), 60-69 years for endometrial cancer (p = 0,211) and 50-59 years for ovarian cancer (p = 0.032). A significant correlation was observed between types of neoplasia and obesity (division by 2 = 25.277, p = 0.046), HPV infection (chi2 = 47.49, p = 0,022), stage (chi = 88.27, p = 0,010) and between age and diagnostic (chi2 = 252.15, p = 0.00017). From 84 cases, 10 have presented ASCUS lesions, 7 HGSIL, 4 carcinoma, 3 LGSIL and 1 AGCUS lesions.
The diagnostic, educational level, age at first birth over 30 years was directly correlated with histological types. In our study, the mains factors correlated with types of neoplasia were obesity, HPV infections, stage and age.
无论是从病例数量的增加还是这些病例所导致的死亡率来看，生殖器癌和乳腺癌在女性病理学中都占据重要地位。
对罗马尼亚东北部地区女性的生殖器癌和乳腺癌及其危险因素进行描述性评估。
我们纳入了105名女性（年龄范围23 - 77岁，平均53.77岁），她们在入院时被诊断为乳腺癌、卵巢癌、子宫内膜癌和宫颈癌，在11个月内居住于雅西“库扎·沃德”医院——妇产科诊所（第一、二和四妇科诊所）以及雅西“埃琳娜·多娜”医院——妇产科诊所（第三妇科诊所）。我们使用了一份特殊问卷来评估危险因素。经过培训的访谈者识别并询问病例。评估了以下参数：婚姻状况、教育水平、初潮年龄、首次性接触年龄、首次生育年龄、产次、自然流产、母乳喂养时间、绝经状态、绝经年龄、癌症家族史、妇科疾病个人史、体重指数、口服避孕药使用情况、激素替代疗法使用情况、环境暴露、巴氏试验。数据收集后，将其编码并纳入MS Excel数据库，以便使用SPSS 13和EpiInfo 3.4.3（2007）软件进行处理。
观察到以下按诊断类型的病例分布：乳腺癌（41例）、宫颈癌（24例）、子宫内膜癌（12例）和卵巢癌（7例）。乳腺癌病例的平均年龄为56.22岁，宫颈癌为46.29岁，子宫内膜癌为59.75岁，卵巢癌为54.86岁。在我们的研究中，乳腺癌最受影响的年龄范围是50 - 59岁（p = 0.00033），宫颈癌是40 - 49岁（p = 0.00257），子宫内膜癌是60 - 69岁（p = 0.211），卵巢癌是50 - 59岁（p = 0.032）。观察到肿瘤类型与肥胖（F = 25.277，p = 0.046）、HPV感染（χ² = 47.49，p = 0.022）、分期（χ = 88.27，p = 0.010）以及年龄与诊断之间存在显著相关性（χ² = 252.15，p = 0.00017）。在84例病例中，10例出现非典型鳞状细胞不能明确意义（ASCUS）病变，7例出现高级别鳞状上皮内病变（HGSIL），4例为癌，3例为低级别鳞状上皮内病变（LGSIL），1例为非典型腺细胞不能明确意义（AGCUS）病变。
诊断、教育水平、首次生育年龄超过30岁与组织学类型直接相关。在我们的研究中，与肿瘤类型相关的主要因素是肥胖、HPV感染、分期和年龄。
