马来西亚女性宫颈病变的组织病理学研究结果。

Histopathological findings for cervical lesions in Malaysian women.

作者信息

Al-Jashamy Karim, Al-Naggar Redhwan Ahmed, San Poil, Mashani M

机构信息

Faculty of Health and Life Sciences, Management and Science University, Selangor, Malaysia.

出版信息

Asian Pac J Cancer Prev. 2009;10(6):1159-62.

PMID:20192603

Abstract

OBJECTIVE

The objective of this study was to determine the histopathological features and cell morphology of various cervical lesions observed among Malaysian women.

METHODOLOGY

A retrospective study was conducted to evaluate 77 cervical cases collected from the histopathology laboratory of Ipoh hospital from 1st January, 2005, to 31st December, 2006.

RESULTS

Cervical intraepithelial neoplasia (CIN) was found in 33 (42%) cases, CIN III accounting for 27%, and CIN I, CIN II and CIN II-III 5% each. The highest rate for CIN cases was 43% in the 41-50 year age group and the lowest rate was 6% in the group aged 61-70 years. Non-keratinizing and metastatic squamous cell carcinomas (SCCs) accounted for 16% and 13%, respectively, the combination being second in majority (29%), followed by adenocarcinoma (17%). The histopathological results showed CIN I to be characterized by mild papillary projections of the epithelium with some degree of nuclear enlargement, pleomorphism, mild koilocytosis, bionucleated cells and a low nucleo-cytoplasmic ratio. CIN II demonstrated typical squamous epithelium with disorganization of the lower part of the epithelium accompanied by nuclear hyperchromatism, an increased nucleo-cytoplasmic ratio, and scanty mitotic figures. CIN III was characterized by pleomorphic nuclei, atypical cells with mitotic figures, nucleo-cytoplasmic ratio, anisokaryosis and hyperchromasia.

CONCLUSION

Lesions related to cervical cancer showed tumor progression correlating with histopathological changes in cell morphology.

摘要

目的

本研究的目的是确定马来西亚女性中观察到的各种宫颈病变的组织病理学特征和细胞形态。

方法

进行了一项回顾性研究，以评估2005年1月1日至2006年12月31日从怡保医院组织病理学实验室收集的77例宫颈病例。

结果

33例（42%）发现宫颈上皮内瘤变（CIN），其中CIN III占27%，CIN I、CIN II和CIN II-III各占5%。CIN病例发生率最高的是41 - 50岁年龄组，为43%，最低的是61 - 70岁年龄组，为6%。非角化性和转移性鳞状细胞癌（SCC）分别占16%和13%，两者合计在多数情况中占第二位（29%），其次是腺癌（17%）。组织病理学结果显示，CIN I的特征是上皮轻度乳头样突起，伴有一定程度的核增大、多形性、轻度挖空细胞、双核细胞和低核质比。CIN II表现为典型的鳞状上皮，上皮下部结构紊乱，伴有核深染、核质比增加和少量有丝分裂象。CIN III的特征是核多形性、有丝分裂象的非典型细胞、核质比、核大小不等和深染。