Huang Y, Huang M-N, Li N, Li X-G, Li N, Wu L-Y
Department of Gynecological Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical University, Beijing, People's Republic of China.
Int J Gynecol Cancer. 2008 Jul-Aug;18(4):755-60. doi: 10.1111/j.1525-1438.2007.01092.x. Epub 2007 Nov 16.
The aim of the present study was to evaluate the relationship between human papillomavirus (HPV) viral load and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. HPV viral load was tested by hybrid capture (HC) II method in 69 normal women, 202 with CIN, and 236 with squamous cervical cancer (SCC). A significant difference in viral load was found between CIN I and CIN II + III. The risk of developing CIN and SCC estimated by OR (odds ratio) increased with elevated viral load (medium viral load: 13.6 for CIN and 54.6 for SCC, high viral load: 10.8 for CIN and 34.8 for SCC, respectively), with correspondent ORs (medium viral load: 11.3 for CIN and 69.4 for SCC, high viral load: 9.8 for CIN and 39.9 for SCC, respectively) after adjusted cofactors such as age, pregnancy, and so on. Hence, HPV viral load detected by HC II might be a useful predictor for women with high risk of development of CIN and cervical cancer.
本研究的目的是评估人乳头瘤病毒（HPV）病毒载量与宫颈上皮内瘤变（CIN）及宫颈癌风险之间的关系。采用杂交捕获（HC）II法对69名正常女性、202名CIN患者和236名宫颈鳞状细胞癌（SCC）患者进行了HPV病毒载量检测。结果发现CIN I与CIN II + III之间的病毒载量存在显著差异。通过比值比（OR）估计，发生CIN和SCC的风险随病毒载量升高而增加（中等病毒载量：CIN为13.6，SCC为54.6；高病毒载量：CIN为10.8，SCC为34.8），在调整年龄、妊娠等协变量后相应的OR值（中等病毒载量：CIN为11.3，SCC为69.4；高病毒载量：CIN为9.8，SCC为39.9）。因此，HC II检测的HPV病毒载量可能是CIN和宫颈癌发生风险较高女性的一个有用预测指标。
