北欧国家 1964-2003 年间诊断为脑和神经系统、甲状腺、眼睛、骨骼和软组织癌症患者的生存趋势，随访至 2006 年底。

Trends in survival of patients diagnosed with cancers of the brain and nervous system, thyroid, eye, bone, and soft tissues in the Nordic countries 1964-2003 followed up until the end of 2006.

机构信息

Department of Clinical- and Registry-based Research, Cancer Registry of Norway, Oslo, Norway.

出版信息

Acta Oncol. 2010 Jun;49(5):673-93. doi: 10.3109/02841861003610200.

DOI:10.3109/02841861003610200

PMID:20192877

Abstract

BACKGROUND

Diagnoses of cancer of the brain, thyroid, eye, bone, and soft tissues are categorised by heterogeneity in disease frequency, survival, aetiology and prospects for curative therapy. In this paper, temporal trends in patient survival in the Nordic countries are considered.

MATERIAL AND METHODS

Age-standardised incidence and mortality rates, 5-year relative survival, and excess mortality rates for varying follow-up periods are presented, as are age-specific 5-year relative survival by country, sex and 5-year diagnostic period.

RESULTS

Brain cancer incidence rates have been rising but mortality has been relatively stable, with 5-year survival uniformly increasing from the early-1970s, particularly in younger patients. Five-year survival from brain cancer among men varies between 45% and 50% for men and 60% to 70% in women, with excess deaths decreasing with time in each of the Nordic populations. Age-standardised incidence rates of thyroid cancer have been mainly increasing during the 1960s and 1970s, although trends thereafter diverge, with 5-year relative survival increasing 20-30 percentage points over the last 40 years to around 80-90%. Thyroid cancer survival is consistently lower in Denmark, particularly in patients diagnosed aged over 60, while there is less geographic variation in excess deaths three months beyond initial diagnosis. Relative survival from eye cancer increased with time from approximately 60% in 1964-1968 to 80% 1999-2003, while for bone sarcoma, incidence rates remained stable, mortality rates declined, and 5-year survival increased slightly to around 55-65%. Soft tissue sarcoma incidence and survival have been slowly increasing since the 1960s, with little variation in survival (around 65%) for the most recent period.

CONCLUSIONS

There have been some notable changes in survival that can be linked to epidemiological and clinical factors in different countries over time. Time-varying proportions of the major histological subtypes might however have affected the survival estimates for a number of the cancer forms reviewed here.

摘要

背景

脑、甲状腺、眼、骨和软组织癌症的诊断因其疾病频率、存活率、病因和治愈疗法的前景而异质性而分类。本文考虑了北欧国家患者生存率的时间趋势。

材料和方法

呈现了年龄标准化发病率和死亡率、5 年相对生存率以及不同随访期的超额死亡率，以及按国家、性别和 5 年诊断期划分的特定年龄 5 年相对生存率。

结果

脑癌发病率一直在上升，但死亡率相对稳定，5 年生存率从 20 世纪 70 年代初开始普遍上升，特别是在年轻患者中。男性脑癌的 5 年生存率在 45%至 50%之间，女性在 60%至 70%之间，每个北欧人群的超额死亡人数随着时间的推移而减少。甲状腺癌的年龄标准化发病率在 20 世纪 60 年代和 70 年代主要呈上升趋势，尽管此后趋势有所不同，5 年相对生存率在过去 40 年中增加了 20-30 个百分点，达到 80-90%左右。丹麦的甲状腺癌生存率一直较低，尤其是在 60 岁以上被诊断的患者中，而在初步诊断后三个月的超额死亡人数方面，地理差异较小。眼癌的相对生存率随时间推移而增加，从 1964-1968 年的约 60%增加到 1999-2003 年的 80%，而骨肉瘤的发病率保持稳定，死亡率下降，5 年生存率略有上升至约 55-65%。自 20 世纪 60 年代以来，软组织肉瘤的发病率和生存率一直在缓慢上升，最近一段时间的生存率（约 65%）变化不大。