新生儿巨细胞病毒感染及其预防
Cytomegalovirus infection in the neonate and its prevention.
作者信息
Stern H
出版信息
Postgrad Med J. 1977 Oct;53(624):588-91. doi: 10.1136/pgmj.53.624.588.
Abstract
About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produce neutralizing antibody in volunteers without significant side effects or detectable virus excretion. The problems of developing such a vaccine for use in man, namely, attenuation, antigenic differences among virus strains, reactivation of latent infection and oncogenicity, are briefly discussed.
摘要
约0.5%的婴儿在子宫内感染巨细胞病毒（CMV）。多达20%的婴儿会智力发育迟缓，另有相当一部分会遭受程度较轻的脑损伤。对CMV疫苗的需求比对风疹疫苗的需求更大。一种经组织培养适应的CMV活毒株已被证明能在志愿者体内产生中和抗体，且无明显副作用或可检测到的病毒排泄。本文简要讨论了开发这种用于人类的疫苗所面临的问题，即减毒、病毒株间的抗原差异、潜伏感染的激活和致癌性。
相似文献
1
Cytomegalovirus infection in the neonate and its prevention.新生儿巨细胞病毒感染及其预防
Postgrad Med J. 1977 Oct;53(624):588-91. doi: 10.1136/pgmj.53.624.588.
2
Vaccination with a Live Attenuated Cytomegalovirus Devoid of a Protein Kinase R Inhibitory Gene Results in Reduced Maternal Viremia and Improved Pregnancy Outcome in a Guinea Pig Congenital Infection Model.在豚鼠先天性感染模型中，接种缺乏蛋白激酶R抑制基因的减毒活巨细胞病毒可降低母体病毒血症并改善妊娠结局。
J Virol. 2015 Oct;89(19):9727-38. doi: 10.1128/JVI.01419-15. Epub 2015 Jul 15.
3
Immunisation trials with live attenuated cytomegalovirus TOWNE 125.减毒活巨细胞病毒TOWNE 125免疫试验。
Infection. 1975;3(2):111-4. doi: 10.1007/BF01641052.
4
A canarypox vector expressing cytomegalovirus (CMV) glycoprotein B primes for antibody responses to a live attenuated CMV vaccine (Towne).一种表达巨细胞病毒（CMV）糖蛋白B的金丝雀痘病毒载体可引发针对减毒活CMV疫苗（汤氏疫苗）的抗体反应。
J Infect Dis. 1999 Sep;180(3):843-6. doi: 10.1086/314951.
5
Prevention of cytomegalovirus disease by Towne strain live attenuated vaccine.托恩株减毒活疫苗预防巨细胞病毒病
Birth Defects Orig Artic Ser. 1984;20(1):271-87.
6
Neutralization of Diverse Human Cytomegalovirus Strains Conferred by Antibodies Targeting Viral gH/gL/pUL128-131 Pentameric Complex.靶向病毒gH/gL/pUL128 - 131五聚体复合物的抗体对多种人巨细胞病毒毒株的中和作用
J Virol. 2017 Mar 13;91(7). doi: 10.1128/JVI.02033-16. Print 2017 Apr 1.
7
DNA vaccines against cytomegalovirus: current progress.抗巨细胞病毒的DNA疫苗：当前进展
Int J Antimicrob Agents. 2002 Mar;19(3):169-72. doi: 10.1016/s0924-8579(01)00492-7.
8
The Effect of Human Immunodeficiency Virus and Cytomegalovirus Infection on Infant Responses to Vaccines: A Review.人类免疫缺陷病毒和巨细胞病毒感染对婴儿疫苗反应的影响：综述。
Front Immunol. 2018 Mar 2;9:328. doi: 10.3389/fimmu.2018.00328. eCollection 2018.
9
[The prevention of cytomegalovirus infection and disease by administration of biological products].[通过施用生物制品预防巨细胞病毒感染和疾病]
Nihon Rinsho. 1998 Jan;56(1):145-50.
10
Immunoprophylaxis of experimental cytomegalovirus infection.实验性巨细胞病毒感染的免疫预防
Ann Microbiol (Paris). 1977 Oct;128(3):399-407.
引用本文的文献
1
Intra-uterine transmission of cytomegalovirus in women known to be immune before conception.已知在受孕前具有免疫力的女性中巨细胞病毒的宫内传播。
J Hyg (Lond). 1984 Feb;92(1):89-95. doi: 10.1017/s0022172400064068.
2
Comparison of enzyme-linked immunosorbent assay, radioimmunoassay, complement fixation, anticomplement immunofluorescence and passive haemagglutination techniques for detecting cytomegalovirus IgG antibody.酶联免疫吸附测定、放射免疫测定、补体结合试验、抗补体免疫荧光法及被动血凝技术检测巨细胞病毒IgG抗体的比较
J Clin Pathol. 1982 Dec;35(12):1345-8. doi: 10.1136/jcp.35.12.1345.
3
Congenital cytomegalovirus infection.先天性巨细胞病毒感染
Arch Dis Child. 1984 Dec;59(12):1120-6. doi: 10.1136/adc.59.12.1120.
4
Congenital cytomegalovirus infection.先天性巨细胞病毒感染
Br Med J (Clin Res Ed). 1987 Jun 6;294(6585):1440-1. doi: 10.1136/bmj.294.6585.1440-a.
5
An early marker of fetal infection after primary cytomegalovirus infection in pregnancy.孕期原发性巨细胞病毒感染后胎儿感染的早期标志物。
Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):718-20. doi: 10.1136/bmj.292.6522.718.
6
Congenital cytomegalovirus infection: a cause of sensorineural hearing loss.先天性巨细胞病毒感染：感音神经性听力损失的一个病因。
Arch Dis Child. 1987 Dec;62(12):1233-7. doi: 10.1136/adc.62.12.1233.
本文引用的文献
1
OBSERVATIONS CONCERNING HUMAN CYTOMEGALOVIRUS INFECTION AND DISEASE.关于人巨细胞病毒感染与疾病的观察
Bull Johns Hopkins Hosp. 1964 Mar;114:181-211.
2
Clinical aspects of cytomegalovirus infection in kidney-graft recipients.肾移植受者巨细胞病毒感染的临床情况
Scand J Infect Dis. 1974;6(4):315-23. doi: 10.3109/inf.1974.6.issue-4.04.
3
Transfusion-acquired cytomegalovirus infection in newborn infants.新生儿输血获得性巨细胞病毒感染
Am J Dis Child. 1974 Oct;128(4):478-83. doi: 10.1001/archpedi.1974.02110290048008.
4
Congenital cytomegalovirus infection: consecutive occurrence due to viruses with similar antigenic compositions.先天性巨细胞病毒感染：由具有相似抗原组成的病毒连续发生。
Pediatrics. 1973 Dec;52(6):788-94.
5
Inapparent congenital cytomegalovirus infection with elevated cord IgM levels. Casual relation with auditory and mental deficiency.脐带血IgM水平升高的先天性巨细胞病毒隐性感染。与听觉和智力缺陷的因果关系。
N Engl J Med. 1974 Feb 7;290(6):291-6. doi: 10.1056/NEJM197402072900601.
6
Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus.暴露于紫外线照射的人巨细胞病毒后仓鼠胚胎成纤维细胞的恶性转化
Virology. 1973 Sep;55(1):53-61. doi: 10.1016/s0042-6822(73)81007-4.
7
Maternal cytomegalovirus excretion and perinatal infection.孕妇巨细胞病毒排泄与围产期感染。
N Engl J Med. 1973 Jul 5;289(1):1-5. doi: 10.1056/NEJM197307052890101.
8
Prospective study of cytomegalovirus infection in pregnancy.孕期巨细胞病毒感染的前瞻性研究。
Br Med J. 1973 May 5;2(5861):268-70. doi: 10.1136/bmj.2.5861.268.
9
Studies of human cytomegalovirus strain variations by kinetic neutralization tests.通过动力学中和试验对人巨细胞病毒毒株变异的研究。
Arch Gesamte Virusforsch. 1972;38(4):297-305. doi: 10.1007/BF01262820.
10
The correlation of maternal cytomegalovirus infection during varying stages in gestation with neonatal involvement.孕期不同阶段母体巨细胞病毒感染与新生儿感染情况的相关性。
J Pediatr. 1972 Jan;80(1):17-20. doi: 10.1016/s0022-3476(72)80446-3.
Zotero 插件