孕期巨细胞病毒感染的前瞻性研究。
Prospective study of cytomegalovirus infection in pregnancy.
作者信息
Stern H, Tucker S M
出版信息
Br Med J. 1973 May 5;2(5861):268-70. doi: 10.1136/bmj.2.5861.268.
Abstract
In a prospective study of cytomegalovirus infection in 1,040 pregnant women in London 319 (42%) of the white Englishwomen but only 28 (10%) of the immigrant Asian women were without antibodies at the onset of pregnancy. Out of 254 susceptible white women and 16 susceptible Asian women 8 (3%) and 3 (16%) respectively experienced primary infection during the course of pregnancy. The overall incidence of fetal infection after primary infection in the mother was almost 50%, and was higher in early pregnancy. One out of the five infected infants was found to be mentally retarded.Reactivation of latent infection was recognized in 0.7-2.9% of pregnant women; this occurred without involving the fetus.
摘要
在一项针对伦敦1040名孕妇的巨细胞病毒感染前瞻性研究中，319名（42%）英国白人女性在妊娠开始时没有抗体，而移民亚洲女性中只有28名（10%）没有抗体。在254名易感白人女性和16名易感亚洲女性中，分别有8名（3%）和3名（16%）在孕期发生了原发性感染。母亲原发性感染后胎儿感染的总体发生率近50%，且在孕早期更高。在5名受感染婴儿中有1名被发现智力发育迟缓。0.7%-2.9%的孕妇出现潜伏感染复发；这种情况发生时未累及胎儿。
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