Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, China.
Yan'an University Medical School, Yan'an, China.
Curr Stem Cell Res Ther. 2019;14(3):239-243. doi: 10.2174/1574888X14666181205122729.
Bone homeostasis is strictly regulated by balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts.Disruption of the balance of activity between osteoblasts and osteoclasts leads to various metabolic bone diseases. Osteoclasts are cells of hematopoietic origin that they are large, multinucleated cells formed by the fusion of precursor cells of monocyte/macrophage lineage, they are unique cells that degrade the bone matrix, activation of transcription factors nuclear factoractivated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation and it plays the role of a master transcription regulator of osteoclast differentiation, meanwhile, NFATc1 could be employed to elicit anabolic effects on bone. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast and osteoblast differentiation as well as a new strategy for promoting bone regeneration in osteopenic disease.
骨稳态是由成骨细胞和破骨细胞的平衡活动严格调节的。成骨细胞和破骨细胞活动之间的平衡被打破会导致各种代谢性骨疾病。破骨细胞是造血来源的细胞，是由单核细胞/巨噬细胞系前体细胞融合形成的大型多核细胞，是降解骨基质的独特细胞，转录因子核因子活化 T 细胞 c1（NFATc1）的激活对于充分的破骨细胞分化是必需的，它在破骨细胞分化中起着主转录调控因子的作用，同时，NFATc1 可用于在骨质疏松症中引发对骨骼的合成代谢作用。在这篇综述中，我们总结了控制破骨细胞和成骨细胞分化过程中 NFATc1 调节的各种机制，以及促进骨质疏松症中骨再生的新策略。
