Department of Gene and Cell Medicine and Mount Sinai School of Medicine, New York, NY, USA.
Immunol Rev. 2010 Mar;234(1):55-75. doi: 10.1111/j.0105-2896.2009.00885.x.
Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non-lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC-restricted lineage to the non-lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non-lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.
树突状细胞（DCs）在小鼠淋巴器官中的研究已经非常广泛，但对于非淋巴组织中 DC 的起源和调控机制知之甚少。本文讨论了最近的证据，这些证据确立了 DC 特异性谱系对非淋巴组织 DC 池的贡献，并讨论了控制非淋巴组织 DC 稳态的机制。我们还回顾了最近的结果，强调了组织 DC 的功能专业化，并讨论了这些发现对组织免疫和新型疫苗策略发展的潜在影响。
