Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.
Immunol Rev. 2010 Mar;234(1):45-54. doi: 10.1111/j.0105-2896.2009.00879.x.
Dendritic cells (DCs) are specialized antigen-presenting cells and essential mediators of immunity and tolerance. This group of cells is heterogeneous in terms of cell-surface markers, anatomic location, and function. Here, we review the development and function of DCs found in lymphoid and non-lymphoid tissues in the steady state. DC and monocyte lineages originate from a common progenitor, the monocyte and dendritic cell progenitor (MDP). The two cell types diverge when MDPs give rise to monocytes and committed DC progenitors (CDPs) in the bone marrow. CDPs give rise to pre-DCs, which migrate from the bone marrow to lymphoid and non-lymphoid tissues to produce the two major subpopulations of lymphoid tissue DCs and non-lymphoid tissue CD103(+) DCs. Within tissues and during development, DC division and homeostasis are regulated by the hormone Flt3L.
树突状细胞 (DCs) 是一种专业的抗原呈递细胞，是免疫和耐受的重要介质。这群细胞在细胞表面标记物、解剖位置和功能方面存在异质性。在这里，我们回顾了在稳态下淋巴组织和非淋巴组织中发现的 DC 的发育和功能。DC 和单核细胞谱系起源于一个共同的祖细胞，即单核细胞和树突状细胞祖细胞 (MDP)。当 MDP 在骨髓中产生单核细胞和定向 DC 祖细胞 (CDP) 时，两种细胞类型就会分化。CDP 产生前 DC，前 DC 从骨髓迁移到淋巴组织和非淋巴组织，产生两种主要的淋巴组织 DC 亚群和非淋巴组织 CD103(+) DC。在组织内和发育过程中，激素 Flt3L 调节 DC 的分裂和稳态。
