Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea.
Immunol Rev. 2010 Mar;234(1):233-46. doi: 10.1111/j.0105-2896.2009.00878.x.
Dendritic cells (DCs) are key regulators of the immune system. They act as professional antigen-presenting cells and are capable of activating naive T cells and stimulating the growth and differentiation of B cells. According to their molecular expression, DCs can be divided into several subsets with different functions. We focus on DC subsets expressing langerin, a C-type lectin. Langerin expression is predominant in skin DCs, but langerin-expressing DCs also exist in mucosal tissue and can be induced by immunization and sometimes by nutrient deficiency. Topical transcutaneous immunization induces langerin(+)CD8 alpha(-) DCs in mesenteric lymph nodes (MLNs), which mediate the production of antigen-specific immunoglobulin A antibody in the intestine. Yet, in one recent study, langerin(+) DCs were generated in gut-associated lymphoid tissue and contributed to the suppressive intestinal immune environment in the absence of retinoic acid. In this review, we focus on the phenotypic and functional characteristics of langerin(+) DCs in the mucosal tissues, especially MLNs.
树突状细胞（DCs）是免疫系统的关键调节者。它们作为专业的抗原呈递细胞，能够激活初始 T 细胞并刺激 B 细胞的生长和分化。根据其分子表达，DC 可分为具有不同功能的几个亚群。我们重点关注表达朗格汉斯细胞（一种 C 型凝集素）的 DC 亚群。朗格汉斯细胞在皮肤 DC 中表达占优势，但在黏膜组织中也存在表达朗格汉斯细胞的 DC，并且可以通过免疫接种和有时通过营养缺乏来诱导。局部透皮免疫接种诱导肠系膜淋巴结（MLN）中朗格汉斯细胞（+）CD8α（-）DC 的产生，其介导肠道中抗原特异性免疫球蛋白 A 抗体的产生。然而，在最近的一项研究中，在肠道相关淋巴组织中生成了朗格汉斯细胞（+）DC，并在没有视黄酸的情况下有助于抑制肠道免疫环境。在这篇综述中，我们重点关注黏膜组织，特别是 MLN 中朗格汉斯细胞（+）DC 的表型和功能特征。
