Laboratory of Microbiology and Immunology, College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea.
Laboratory of Microbiology, College of Pharmacy, Ajou University, Suwon 443-749, Korea.
Immune Netw. 2015 Feb;15(1):1-8. doi: 10.4110/in.2015.15.1.1. Epub 2015 Feb 17.
Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell.
先天免疫细胞监测我们身体表面下的抗原物质，并对内部和外部危险信号做出一线反应。树突状细胞 (DC) 是先天免疫细胞的一个子集，是在免疫反应中发挥多种作用的关键哨兵，从作为主要调节剂到通过抗原特异性信号引发适应性免疫反应。在肠道中，DC 在稳态条件下遇到外源性、无害的食物抗原以及大量共生微生物。在其他情况下，它们必须对抗病原微生物以防止感染。在这篇综述中，我们重点关注肠道 DC 在维持肠道免疫稳态中的功能。具体来说，我们描述了肠道 DC 如何影响 B 细胞产生 IgA 以及影响 T 细胞独特亚群的产生。
