Wang Qi-Zhao, Lu Ying-Hui, Jiang Nan, Diao Yong, Xu Rui-An
Institute of Molecular Medicine, Huaqiao University, Quanzhou, Fujian 362021, P.R. China.
Chin J Cancer. 2010 Mar;29(3):248-53. doi: 10.5732/cjc.009.10668.
Stem cells use asymmetric and symmetric cell division to generate progeny. Symmetric cell division is defined as the generation of daughter cells that are destined to acquire the same fate. Stem cells divide asymmetrically to generate one daughter with a stem-cell fate and one daughter with different fate. Disruption of the machinery that regulates asymmetric division may be a reason for the generation of cancer. The asymmetric mechanism is maintained by cell polarity factors, cell fate determinants, and the spindle apparatus. The mutation or dysregulation of these factors may change stem cells from asymmetric to symmetric cell division, then leading to tumorigenesis. Therefore, further study is needed on the mechanisms of stem cell control between asymmetric and symmetric cell division, as well as the relationships among stem cells, cancer stem cells, and tumor cells. It may bring us a new approach for the resistance, recurrence, and metastasis of tumors.
干细胞通过不对称和对称细胞分裂来产生子代细胞。对称细胞分裂被定义为产生注定具有相同命运的子代细胞。干细胞进行不对称分裂以产生一个具有干细胞命运的子代细胞和一个具有不同命运的子代细胞。调节不对称分裂的机制受到破坏可能是癌症产生的一个原因。不对称机制由细胞极性因子、细胞命运决定因素和纺锤体装置维持。这些因素的突变或失调可能会使干细胞从不对称细胞分裂转变为对称细胞分裂，进而导致肿瘤发生。因此，需要进一步研究干细胞在不对称和对称细胞分裂之间的调控机制，以及干细胞、癌症干细胞和肿瘤细胞之间的关系。这可能会为肿瘤的耐药性、复发和转移带来新的解决方法。
