Wang Yifan, Zhou Binhua P
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40506, USA.
Chin J Cancer. 2011 Sep;30(9):603-11. doi: 10.5732/cjc.011.10226.
Breast cancer is the most common cancer in women, and approximately 90% of breast cancer deaths are caused by local invasion and distant metastasis of tumor cells. Epithelial-mesenchymal transition (EMT) is a vital process for large-scale cell movement during morphogenesis at the time of embryonic development. Tumor cells usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. Several transcription factors and signals are involved in these events. In this review, we summarize recent advances in breast cancer researches that have provided new insights in the molecular mechanisms underlying EMT regulation during breast cancer progression and metastasis. We especially focus on the molecular pathways that control EMT.
乳腺癌是女性中最常见的癌症，约90%的乳腺癌死亡是由肿瘤细胞的局部侵袭和远处转移引起的。上皮-间质转化（EMT）是胚胎发育时期形态发生过程中大规模细胞运动的关键过程。肿瘤细胞利用这一发育程序来执行肿瘤发生和转移的多步骤过程。一些转录因子和信号参与了这些事件。在本综述中，我们总结了乳腺癌研究的最新进展，这些进展为乳腺癌进展和转移过程中EMT调控的分子机制提供了新的见解。我们特别关注控制EMT的分子途径。
