[生活方式相关、生理及生化因素对主动脉弓钙化的影响]

[Impact on calcification of aortic arch by lifestyle-related, physiologic and biochemical factors].

作者信息

Zhou Hai-Lin, Jiang Chao-Qiang, Lam Tai-Hing, Cheng Kar-Keung, Liu Bin, Zhang Wei-Sen, Xu Lin, Jin Ya-Li, Zhu Tong, Gn Thomas

机构信息

The Guangzhou No.12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Aug;30(8):776-9.

PMID:20193196

Abstract

OBJECTIVE

To explore the impact of lifestyle-related, physiological and biochemical factors on aortic arch calcification (AAC).

METHODS

20 430 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study. All the subjects received face-to-face interviews to collect detailed information on their socio-demographic background, occupational exposures, living environment, lifestyle, family and personal disease histories, and received a physical examination and tests including 12-lead ECG, chest radiograph, and pulmonary function testing. Each subject was screened for a range of fasting biochemical parameters. Radiographs were reviewed by two senior radiologists. 300 radiographs were independently read by the two radiologists to assess agreement using Kappa coefficient. Logistic regression was used to assess the association between life style, physiological and biochemical factors and AAC.

RESULTS

(1) The rate of agreement on diagnosis for the two radiologists was 85% and Kappa coefficient was 0.68 (P < 0.01) which showed a moderate agreement between the two radiologists. (2) Except hypertension, the subjects were significantly different on their lifestyle, physiological and biochemical factors in both men and women (P < 0.05). (3) AAC was significantly associated with older age, smoking status, LDL-C, and hypertension (P < 0.01) in both genders. ORs (95%CI) indicated the following results: age was 1.11 (1.10 - 1.12) in men and 1.12 (1.12 - 1.13) in women;smoking as 1.31 (1.17 - 1.47) in men and 1.31 (1.09 - 1.57) in women; LDL-C as 1.16 (1.06 - 1.27) in men and 1.38 (1.22 - 1.56) in women, hypertension as 1.33 (1.18 - 1.50) in men and 1.27 (1.18 - 1.38) in women. However, diabetes was found to be associated with an increased risk of AAC in women [OR(95%CI)] 1.38 (1.22 - 1.56).

CONCLUSION

Age, smoking, hypertension and Low-density lipoprotein level were risk factors to both genders, on AAC, while diabetes increased the risk of AAC, in women.

摘要

目的

探讨生活方式、生理和生化因素对主动脉弓钙化（AAC）的影响。

方法

本研究纳入了广州生物样本库队列研究第一和第二招募阶段的20430名年龄在50至85岁之间的受试者。所有受试者均接受面对面访谈，以收集其社会人口学背景、职业暴露、生活环境、生活方式、家族和个人疾病史的详细信息，并接受包括12导联心电图、胸部X光片和肺功能测试在内的体格检查和检测。对每位受试者进行一系列空腹生化参数筛查。X光片由两位资深放射科医生进行评估。两位放射科医生独立阅读300张X光片，使用Kappa系数评估一致性。采用逻辑回归分析评估生活方式、生理和生化因素与AAC之间的关联。

结果

（1）两位放射科医生对诊断的一致率为85%，Kappa系数为0.68（P<0.01），表明两位放射科医生之间存在中度一致性。（2）除高血压外，男性和女性在生活方式、生理和生化因素方面均存在显著差异（P<0.05）。（3）AAC在男性和女性中均与年龄较大、吸烟状况、低密度脂蛋白胆固醇（LDL-C）和高血压显著相关（P<0.01）。比值比（95%置信区间）显示以下结果：男性年龄为1.11（1.10 - 1.12），女性为1.12（1.12 - 1.13）；男性吸烟为1.31（1.17 - 1.47），女性为1.31（1.09 - 1.57）；男性LDL-C为1.16（1.06 - 1.27），女性为1.38（1.22 - 1.56），男性高血压为1.33（1.18 - 1.50），女性为1.27（1.18 - 1.38）。然而，发现糖尿病与女性AAC风险增加相关[比值比（95%置信区间）]为1.38（1.22 - 1.56）。